PMID- 24148289
OWN - NLM
STAT- MEDLINE
DCOM- 20140715
LR  - 20131126
IS  - 1872-7077 (Electronic)
IS  - 1382-6689 (Linking)
VI  - 36
IP  - 3
DP  - 2013 Nov
TI  - Detrimental effects of cement mortar and fly ash mortar on asthma progression.
PG  - 1087-96
LID - S1382-6689(13)00202-0 [pii]
LID - 10.1016/j.etap.2013.09.010 [doi]
AB  - Currently, concrete additive materials are used worldwide to improve properties 
      of concrete production and to reduce the total cost of the materials used in the 
      concrete. However, the effects of exposure to various gases emitted from mortar 
      mixed with additive materials are poorly understood. To evaluate the pattern of 
      gas emission from cement mortar and additives, the emission levels of gas 
      including ammonia (NH3) and volatile organic compounds (VOCs) were measured from 
      two different mortar types, Ordinary Portland Cement (OPC), and OPC with fly ash 
      on various time points after manufacture. On days 1, 3, 10 and 30 after 
      manufacture, moderate concentrations of NH3 (4, 9, 12 and 5 ppm) were measured in 
      OPC mortar (24h, 150 mm x 150 mm x 50 mm), whereas higher concentrations of NH3 
      (73, 55, 20 and 5 ppm) were measured in OPC mortar with fly ash (24h, 150 mm x 
      150 mm x 50 mm). Furthermore, the concentration of VOCs was more than 10 ppm on 
      1, 3, and 10 days of age in OPC and OPC with fly ash mortars. To examine the 
      mortars' allergic effects on the respiratory system, mice were sensitized with 
      ovalbumin (OVA) and divided into four groups: normal, asthma control, OPC mortar 
      and OPC mortar with fly ash. The mice were housed in corresponding group cage for 
      10 days with OVA challenges to induce asthma. Histopathologically, increased 
      infiltration of lymphocytes was observed in the lung perivascular area of mice 
      housed in OPC mortar and OPC mortar with fly ash cages compared to lungs of 
      asthma control mice. Moreover, severe bronchial lumen obstruction and increased 
      hypertrophy of bronchial epithelial cells (p<0.05) were observed in the OPC 
      mortar with fly ash group compared to OPC mortar or asthma control groups. Lungs 
      of the two mortar groups generally expressed higher levels of genes related with 
      asthma, including IL-4, eotaxin and epidermal growth factor (EGF) compared to 
      lungs of asthma control mice. Additionally, the OPC mortar with fly ash group 
      showed higher expression of IL-5, 13 and monocyte chemoattractant protein-1 
      (MCP-1) compared to the asthma control group. These results indicate that OPC 
      mortar and OPC mortar with fly ash might exacerbate asthma.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Cho, Ara
AU  - Cho A
AD  - Biosafety Research Institute and Laboratory of Pathology, College of Veterinary 
      Medicine, Chonbuk National University, Jeonju 561-756, South Korea.
FAU - Jang, Hong-Seok
AU  - Jang HS
FAU - Roh, Yoon Seok
AU  - Roh YS
FAU - Park, Hee Jin
AU  - Park HJ
FAU - Talha, A F S M
AU  - Talha AF
FAU - So, Seung-Young
AU  - So SY
FAU - Lim, Chae Woong
AU  - Lim CW
FAU - Kim, Bumseok
AU  - Kim B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130930
PL  - Netherlands
TA  - Environ Toxicol Pharmacol
JT  - Environmental toxicology and pharmacology
JID - 9612020
RN  - 0 (Coal Ash)
RN  - 0 (Gases)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 7664-41-7 (Ammonia)
RN  - 9006-59-1 (Ovalbumin)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Ammonia/analysis
MH  - Animals
MH  - Asthma/*chemically induced/genetics/pathology
MH  - Coal Ash/analysis/*toxicity
MH  - Construction Materials/analysis/*toxicity
MH  - Disease Progression
MH  - Female
MH  - Gases/analysis
MH  - Gene Expression Regulation/drug effects
MH  - Hydrocortisone/blood
MH  - Immunoglobulin E/analysis
MH  - Lung/pathology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/immunology
MH  - Particle Size
MH  - Real-Time Polymerase Chain Reaction
OTO - NOTNLM
OT  - Asthma
OT  - Cement mortar
OT  - Fly ash
OT  - Mice
OT  - NH(3)
EDAT- 2013/10/24 06:00
MHDA- 2014/07/16 06:00
CRDT- 2013/10/24 06:00
PHST- 2013/07/08 00:00 [received]
PHST- 2013/09/20 00:00 [accepted]
PHST- 2013/10/24 06:00 [entrez]
PHST- 2013/10/24 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - S1382-6689(13)00202-0 [pii]
AID - 10.1016/j.etap.2013.09.010 [doi]
PST - ppublish
SO  - Environ Toxicol Pharmacol. 2013 Nov;36(3):1087-96. doi: 
      10.1016/j.etap.2013.09.010. Epub 2013 Sep 30.