PMID- 24148391
OWN - NLM
STAT- MEDLINE
DCOM- 20140603
LR  - 20131023
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 116
DP  - 2013 Nov 15
TI  - Carbon nanotubes reinforced hollow fiber solid phase microextraction for the 
      determination of strychnine and brucine in urine.
PG  - 188-94
LID - S0039-9140(13)00448-7 [pii]
LID - 10.1016/j.talanta.2013.05.025 [doi]
AB  - A mixed matrix membrane (MMM), based on carbon nanotubes (CNTs) and hollow fiber 
      (HF), was prepared and combined with solid phase microextraction (SPME) mode to 
      determine strychnine and brucine in urine. This MMM was prepared by dispersing 
      CNTs in water via surfactant assistance, and then immobilizing CNTs into the 
      pores of HF by capillary forces and sonification. The prepared carbon nanotubes 
      reinforced hollow fiber (CNTs-HF) was subsequently wetted by a few microliters of 
      organic solvent (1-octanol), and then applied to extract the target analytes in 
      direct immersion sampling mode. After extraction, analytes were desorbed via 
      ultrasonic-assisted effect, and then detected via high-performance liquid 
      chromatography (HPLC). To achieve the highest extraction efficiency, main 
      extraction parameters such as the type and amount of surfactant, the diameter and 
      doping level of CNTs, extraction time, desorption condition, pH value, stirring 
      rate and volume of the donor phase were optimized. Under the optimum extraction 
      conditions, the method showed good linearity ranges with correlation coefficients 
      higher than 0.9990, good repeatability and batch-to-batch reproducibility with 
      relative standard deviations (RSDs) less than 6% and 5% for strychnine and 
      brucine, respectively, and low limits of detection (0.7 and 0.9 microg L(-1) for 
      strychnine and brucine, respectively). The recoveries were in the range of 
      83.81-116.14% at three spiked levels. The developed method was successfully 
      applied to real urine sample with mean relative recoveries of 94.28% and 91.30% 
      for strychnine and brucine, respectively. The developed method shows comparable 
      results against reference methods and is a simple, green, and cost-effective 
      microextraction technique.
CI  - (c) 2013 Elsevier B.V. All rights reserved.
FAU - Song, Xin-Yue
AU  - Song XY
AD  - Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory 
      for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, 
      Chinese Academy of Sciences, Lanzhou 730000, PR China; University of Chinese 
      Academy of Sciences, Beijing 100039, PR China.
FAU - Shi, Yan-Ping
AU  - Shi YP
FAU - Chen, Juan
AU  - Chen J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130516
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
RN  - 0 (Membranes, Artificial)
RN  - 0 (Nanotubes, Carbon)
RN  - 6NG17YCK6H (brucine)
RN  - H9Y79VD43J (Strychnine)
RN  - NV1779205D (1-Octanol)
SB  - IM
MH  - 1-Octanol
MH  - Chromatography, High Pressure Liquid
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Limit of Detection
MH  - Membranes, Artificial
MH  - Nanotubes, Carbon/*chemistry
MH  - Reproducibility of Results
MH  - Solid Phase Microextraction/*methods
MH  - Strychnine/*analogs & derivatives/*isolation & purification
OTO - NOTNLM
OT  - Brucine
OT  - CNTs-HF
OT  - CNTs-HF-SPME
OT  - HF
OT  - HF-SPME
OT  - HPLC
OT  - HPLC-PDA
OT  - Hollow fiber
OT  - MMM
OT  - MWCNTs
OT  - Multi-walled carbon nanotubes
OT  - Solid-phase microextraction
OT  - Strychnine
OT  - Surfactant
OT  - carbon nanotubes reinforced hollow fiber
OT  - carbon nanotubes reinforced hollow fiber solid-phase microextraction
OT  - high-performance liquid chromatography
OT  - high-performance liquid chromatography photodiode array detection
OT  - hollow fiber
OT  - hollow fiber solid-phase microextraction
OT  - mixed matrix membrane
OT  - multi-walled carbon nanotubes
EDAT- 2013/10/24 06:00
MHDA- 2014/06/04 06:00
CRDT- 2013/10/24 06:00
PHST- 2013/03/01 00:00 [received]
PHST- 2013/05/09 00:00 [revised]
PHST- 2013/05/11 00:00 [accepted]
PHST- 2013/10/24 06:00 [entrez]
PHST- 2013/10/24 06:00 [pubmed]
PHST- 2014/06/04 06:00 [medline]
AID - S0039-9140(13)00448-7 [pii]
AID - 10.1016/j.talanta.2013.05.025 [doi]
PST - ppublish
SO  - Talanta. 2013 Nov 15;116:188-94. doi: 10.1016/j.talanta.2013.05.025. Epub 2013 
      May 16.