PMID- 2414848
OWN - NLM
STAT- MEDLINE
DCOM- 19851219
LR  - 20190618
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 230
IP  - 4729
DP  - 1985 Nov 29
TI  - Amino acid homology between the encephalitogenic site of myelin basic protein and 
      virus: mechanism for autoimmunity.
PG  - 1043-5
AB  - Amino acid sequence homology was found between viral and host encephalitogenic 
      protein. Immune responses were then generated in rabbits by using the viral 
      peptide that cross-reacts with the self protein. Mononuclear cell infiltration 
      was observed in the central nervous systems of animals immunized with the viral 
      peptide. Myelin basic protein (MBP) is a host protein whose encephalitogenic site 
      of ten amino acids induces experimental allergic encephalomyelitis. By computer 
      analysis, hepatitis B virus polymerase (HBVP) was found to share six consecutive 
      amino acids with the encephalitogenic site of rabbit MBP. Rabbits given 
      injections of a selected eight- or ten-amino acid peptide from HBVP made antibody 
      that reacted with the predetermined sequences of HBVP and also with native MBP. 
      Peripheral blood mononuclear cells from the immunized rabbits proliferated when 
      incubated with either MBP or HBVP. Central nervous system tissue taken from these 
      rabbits had a histologic picture reminiscent of experimental allergic 
      encephalomyelitis. Thus, viral infection may trigger the production of antibodies 
      and mononuclear cells that cross-react with self proteins by a mechanism termed 
      molecular mimicry. Tissue injury from the resultant autoallergic event can take 
      place in the absence of the infectious virus that initiated the immune response.
FAU - Fujinami, R S
AU  - Fujinami RS
FAU - Oldstone, M B
AU  - Oldstone MB
LA  - eng
GR  - AG-04342/AG/NIA NIH HHS/United States
GR  - AI-07007/AI/NIAID NIH HHS/United States
GR  - NS-12428/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Myelin Basic Protein)
RN  - 0 (Viral Proteins)
RN  - EC 2.7.7.6 (DNA-Directed RNA Polymerases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Autoimmune Diseases/immunology
MH  - Cross Reactions
MH  - *DNA-Directed RNA Polymerases/immunology
MH  - Encephalomyelitis, Autoimmune, Experimental/immunology/*microbiology
MH  - Hepatitis B virus/analysis/*immunology
MH  - *Myelin Basic Protein/immunology
MH  - *Viral Proteins/immunology
EDAT- 1985/11/29 00:00
MHDA- 1985/11/29 00:01
CRDT- 1985/11/29 00:00
PHST- 1985/11/29 00:00 [pubmed]
PHST- 1985/11/29 00:01 [medline]
PHST- 1985/11/29 00:00 [entrez]
AID - 10.1126/science.2414848 [doi]
PST - ppublish
SO  - Science. 1985 Nov 29;230(4729):1043-5. doi: 10.1126/science.2414848.