PMID- 24148604
OWN - NLM
STAT- MEDLINE
DCOM- 20140206
LR  - 20131209
IS  - 1879-3169 (Electronic)
IS  - 0378-4274 (Linking)
VI  - 224
IP  - 1
DP  - 2014 Jan 3
TI  - Rutin activates the MAPK pathway and BDNF gene expression on beta-amyloid induced 
      neurotoxicity in rats.
PG  - 108-13
LID - S0378-4274(13)01353-2 [pii]
LID - 10.1016/j.toxlet.2013.10.010 [doi]
AB  - Flavonoids are present in foods such as fruits and vegetables. A relationship 
      between the consumption of flavonoid-rich foods and prevention of human disease 
      including neurodegenerative disorders has been demonstrated. We assessed the 
      effect of rutin (3,3',4',5,7-pentahydroxyflavone-3-rhamnoglucoside) on the 
      mitogen-activated protein kinase (MAPK) pathway, memory retrieval and oxidative 
      stress in rats injected with beta-amyloid (Abeta), which is implicated to have an 
      important role in Alzheimer's disease (AD). Abeta was injected bilaterally in the 
      deep frontal cortex of rat brain. Next, rutin and saline were injected (i.p.) for 
      3 weeks. In comparison to the control group, rutin significantly increased 
      extracellular signal-regulated protein kinase 1 (ERK1), cAMP response 
      element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) gene 
      expression in the hippocampus of rats. Rutin (100 mg/kg) significantly increased 
      memory retrieval compared to the control group. Malondialdehyde (MDA) level in 
      the hippocampus of the rutin group was significantly lower than those in the 
      control group. The content of sulfhydryl groups in the rutin group was higher 
      than that in the control group. The findings show a possibility that rutin may 
      have beneficial effects against neurotoxicity of Abeta on memory in rats.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Moghbelinejad, Sahar
AU  - Moghbelinejad S
AD  - Cellular and Molecular Research Centre, Qazvin University of Medical Sciences, 
      Qazvin, Iran; Department of Genetics, Qazvin University of Medical Sciences, 
      Qazvin, Iran.
FAU - Nassiri-Asl, Marjan
AU  - Nassiri-Asl M
FAU - Farivar, Taghi Naserpour
AU  - Farivar TN
FAU - Abbasi, Esmail
AU  - Abbasi E
FAU - Sheikhi, Mehdi
AU  - Sheikhi M
FAU - Taghiloo, Mina
AU  - Taghiloo M
FAU - Farsad, Farzaneh
AU  - Farsad F
FAU - Samimi, Amir
AU  - Samimi A
FAU - Hajiali, Farid
AU  - Hajiali F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131020
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 5G06TVY3R7 (Rutin)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
SB  - IM
MH  - Amyloid beta-Peptides/*toxicity
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cyclic AMP Response Element-Binding Protein/physiology
MH  - Extracellular Signal-Regulated MAP Kinases/physiology
MH  - Gene Expression Regulation/*drug effects
MH  - MAP Kinase Signaling System/*drug effects
MH  - Male
MH  - Neurotoxicity Syndromes/*prevention & control
MH  - Rats
MH  - Rats, Wistar
MH  - Rutin/*pharmacology
OTO - NOTNLM
OT  - AD
OT  - Akt/PKB
OT  - Alzheimer's disease
OT  - Arc
OT  - Abeta
OT  - BDNF
OT  - CAT
OT  - CREB
OT  - ERK1/2
OT  - GPx
OT  - GSH
OT  - JNK
OT  - MAP kinase
OT  - MCAO
OT  - MDA
OT  - MEK1/2
OT  - Memory
OT  - Neurotoxicity
OT  - PBS
OT  - PI3K
OT  - PTZ
OT  - ROS
OT  - Rutin
OT  - SH
OT  - SOD
OT  - TrkB
OT  - activity-regulated cytoskeleton-associated protein
OT  - brain-derived neurotrophic factor
OT  - c-Jun N-terminal kinase
OT  - cAMP response element-binding protein
OT  - catalase
OT  - extracellular signal-regulated protein kinase
OT  - glutathione
OT  - glutathione peroxidase
OT  - i.p.
OT  - interaperitoneally
OT  - mTor
OT  - malondialdehyde
OT  - mammalian target of rapamycin
OT  - middle cerebral artery occlusion
OT  - mitogen activated kinase kinase
OT  - mitogen-activated protein kinase
OT  - pentylenetetrazole
OT  - phosphate buffered saline
OT  - phosphatidyl inositiol 3-kinase
OT  - protein kinase B
OT  - reactive oxygen species
OT  - sulfhydryl
OT  - superoxide dismutase
OT  - tropomyosin receptor kinase B
OT  - beta-amyloid
EDAT- 2013/10/24 06:00
MHDA- 2014/02/07 06:00
CRDT- 2013/10/24 06:00
PHST- 2013/09/02 00:00 [received]
PHST- 2013/10/11 00:00 [revised]
PHST- 2013/10/14 00:00 [accepted]
PHST- 2013/10/24 06:00 [entrez]
PHST- 2013/10/24 06:00 [pubmed]
PHST- 2014/02/07 06:00 [medline]
AID - S0378-4274(13)01353-2 [pii]
AID - 10.1016/j.toxlet.2013.10.010 [doi]
PST - ppublish
SO  - Toxicol Lett. 2014 Jan 3;224(1):108-13. doi: 10.1016/j.toxlet.2013.10.010. Epub 
      2013 Oct 20.