PMID- 24149828
OWN - NLM
STAT- MEDLINE
DCOM- 20141007
LR  - 20220410
IS  - 1468-3296 (Electronic)
IS  - 0040-6376 (Linking)
VI  - 69
IP  - 9
DP  - 2014 Sep
TI  - The Clinical COPD Questionnaire: response to pulmonary rehabilitation and minimal 
      clinically important difference.
PG  - 793-8
LID - 10.1136/thoraxjnl-2013-204119 [doi]
AB  - BACKGROUND: The Clinical COPD Questionnaire (CCQ) is a simple 10-item, 
      health-related quality of life questionnaire (HRQoL) with good psychometric 
      properties. However, little data exists regarding the responsiveness of the CCQ 
      to pulmonary rehabilitation (PR) or the minimal clinically important difference 
      (MCID). The study aims were to assess the responsiveness of the CCQ to PR, to 
      compare the responsiveness of the CCQ to other HRQoL questionnaires and to 
      provide estimates for the MCID. METHODS: The CCQ, St George's Respiratory 
      Questionnaire (SGRQ), Chronic Respiratory Questionnaire (CRQ) and COPD Assessment 
      Test (CAT) were measured in 261 patients with COPD before and after outpatient 
      PR. Pre to post PR changes and Cohen's effect size were calculated. Changes in 
      CCQ were compared with changes in other HRQoL questionnaires. Using an 
      anchor-based approach and receiver operating characteristic (ROC) curves, the CCQ 
      change cutoffs that identified patients achieving the known MCID for other health 
      status questionnaires with PR were identified. RESULTS: The CCQ, SGRQ, CRQ and 
      CAT all significantly improved with PR with an effect size of -0.39, -0.33, 0.62 
      and -0.25, respectively. CCQ change correlated significantly with change in SGRQ, 
      CRQ and CAT (r=0.48, -0.56, 0.54, respectively; all p<0.001). ROC curves 
      consistently identified a CCQ change cutoff of -0.4 as the best discriminating 
      value to identify the MCID for the SGRQ, CRQ and CAT (area under curve: 0.71, 
      0.75 and 0.77, respectively; all p<0.001). CONCLUSIONS: The CCQ is responsive to 
      PR with an estimated clinically important improvement of -0.4 points. The CCQ is 
      a practical alternative to more time-consuming measures of HRQoL.
CI  - Published by the BMJ Publishing Group Limited. For permission to use (where not 
      already granted under a licence) please go to 
      http://group.bmj.com/group/rights-licensing/permissions.
FAU - Kon, Samantha S C
AU  - Kon SS
AD  - NIHR Respiratory Biomedical Research Unit, Royal Brompton & Harefield NHS 
      Foundation Trust and Imperial College, Harefield, UK.
FAU - Dilaver, Deniz
AU  - Dilaver D
AD  - Harefield Pulmonary Rehabilitation Unit, Royal Brompton & Harefield NHS 
      Foundation Trust, Harefield, UK.
FAU - Mittal, Manvi
AU  - Mittal M
AD  - NIHR Respiratory Biomedical Research Unit, Royal Brompton & Harefield NHS 
      Foundation Trust and Imperial College, Harefield, UK.
FAU - Nolan, Claire M
AU  - Nolan CM
AD  - NIHR Respiratory Biomedical Research Unit, Royal Brompton & Harefield NHS 
      Foundation Trust and Imperial College, Harefield, UK Harefield Pulmonary 
      Rehabilitation Unit, Royal Brompton & Harefield NHS Foundation Trust, Harefield, 
      UK.
FAU - Clark, Amy L
AU  - Clark AL
AD  - Harefield Pulmonary Rehabilitation Unit, Royal Brompton & Harefield NHS 
      Foundation Trust, Harefield, UK.
FAU - Canavan, Jane L
AU  - Canavan JL
AD  - NIHR Respiratory Biomedical Research Unit, Royal Brompton & Harefield NHS 
      Foundation Trust and Imperial College, Harefield, UK.
FAU - Jones, Sarah E
AU  - Jones SE
AD  - NIHR Respiratory Biomedical Research Unit, Royal Brompton & Harefield NHS 
      Foundation Trust and Imperial College, Harefield, UK.
FAU - Polkey, Michael I
AU  - Polkey MI
AD  - NIHR Respiratory Biomedical Research Unit, Royal Brompton & Harefield NHS 
      Foundation Trust and Imperial College, Harefield, UK.
FAU - Man, William D-C
AU  - Man WD
AD  - NIHR Respiratory Biomedical Research Unit, Royal Brompton & Harefield NHS 
      Foundation Trust and Imperial College, Harefield, UK Harefield Pulmonary 
      Rehabilitation Unit, Royal Brompton & Harefield NHS Foundation Trust, Harefield, 
      UK.
LA  - eng
GR  - CTF-01-12-04/DH_/Department of Health/United Kingdom
GR  - DHCS/07/07/009/DH_/Department of Health/United Kingdom
GR  - G1002113/MRC_/Medical Research Council/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131022
PL  - England
TA  - Thorax
JT  - Thorax
JID - 0417353
SB  - IM
MH  - Aged
MH  - Area Under Curve
MH  - Exercise Test
MH  - Female
MH  - Humans
MH  - Male
MH  - Pulmonary Disease, Chronic Obstructive/physiopathology/*rehabilitation
MH  - *Quality of Life
MH  - ROC Curve
MH  - Single-Blind Method
MH  - Spirometry
MH  - *Surveys and Questionnaires
OTO - NOTNLM
OT  - COPD Pathology
OT  - Pulmonary Rehabilitation
EDAT- 2013/10/24 06:00
MHDA- 2014/10/08 06:00
CRDT- 2013/10/24 06:00
PHST- 2013/10/24 06:00 [entrez]
PHST- 2013/10/24 06:00 [pubmed]
PHST- 2014/10/08 06:00 [medline]
AID - thoraxjnl-2013-204119 [pii]
AID - 10.1136/thoraxjnl-2013-204119 [doi]
PST - ppublish
SO  - Thorax. 2014 Sep;69(9):793-8. doi: 10.1136/thoraxjnl-2013-204119. Epub 2013 Oct 
      22.