PMID- 24150706
OWN - NLM
STAT- MEDLINE
DCOM- 20140902
LR  - 20211021
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 252
IP  - 4
DP  - 2014 Apr
TI  - Diagnosis of subretinal neovascularization associated with idiopathic juxtafoveal 
      retinal telangiectasia - fluorescein angiography versus spectral-domain optical 
      coherence tomography.
PG  - 549-53
LID - 10.1007/s00417-013-2491-4 [doi]
AB  - BACKGROUND: To compare ability of fluorescein angiography (FFA) and 
      spectral-domain optical coherence tomography (SD-OCT) to diagnose subretinal 
      neovascularization (SRNV) secondary to idiopathic juxtafoveal retinal 
      telangiectasia (IJRT) type 2A. METHODS: Two masked observers evaluated FFA and 
      SD-OCT images separately to diagnose the presence of SRNV in 65 eyes of 36 
      patients. A third masked observer diagnosed SRNV on color fundus photo. Presence 
      of SRNV on color fundus photo was defined as presence of subretinal hemorrhage, 
      thickening of retina, and/or visible membrane at the macula. Presence of SRNV on 
      FFA was defined when there was hyperfluorescence in early phase with increase in 
      intensity and size in the late phase; presence of membrane, large irregular 
      lesion, hypofluorescence due to subretinal haemorrhage. SRNV on SD-OCT was 
      defined as the presence of thickening of the retinal pigment 
      epithelium-choriocapillaris complex with or without intraretinal fluid or 
      subretinal fluid and associated with intraretinal hyperreflective area with 
      retinal thickening. RESULTS: Interobserver agreement (Kappa) for diagnosis of 
      SRNV on FFA and SD-OCT was 0.373 (95 % CI, 0.106-0.617) and 0.775 (95 % CI, 
      0.612-0.899) respectively. The sensitivity and specificity of FFA were 52.3 % and 
      70.0 % respectively. With regard to SD-OCT, the sensitivity and specificity were 
      72.7 % and 64.1 % respectively in reference to color photograph. The negative 
      predictive value (NPV) of SD-OCT (80.6 %) was higher than FFA (73.7 %). When we 
      considered only the presence of subretinal hemorrhage on color photograph as a 
      confirmed diagnosis of SRNV and compared the diagnostic ability of FFA and 
      SD-OCT, we found that the FFA had poor sensitivity (58.3 %) but a better 
      specificity (71.8 %) than SD-OCT, which had sensitivity of 75 % and specificity 
      of 64 % (Tables 1 and 2). However, the negative predictive value (NPV) of SD-OCT 
      (89.29 %) was slightly better than FFA (84.85 %). CONCLUSION: Interobserver 
      agreement between the observers was better for SD-OCT than for FFA in making the 
      diagnosis of SRNV. SD-OCT is a better diagnostic modality than FFA for ruling out 
      the presence of SRNV.
FAU - Chhablani, Jay
AU  - Chhablani J
AD  - Srimati Kanuri Santhamma Vitreo-Retina Service, L.V. Prasad Eye Institute, L. V. 
      Prasad Marg, Banjara Hills, Hyderabad, India.
FAU - Mithal, Kopal
AU  - Mithal K
FAU - Rao, Harsha
AU  - Rao H
FAU - Narayanan, Raja
AU  - Narayanan R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20131023
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
CIN - Graefes Arch Clin Exp Ophthalmol. 2014 Nov;252(11):1863. PMID: 25196460
CIN - Graefes Arch Clin Exp Ophthalmol. 2014 Nov;252(11):1861. PMID: 25308781
MH  - Aged
MH  - False Negative Reactions
MH  - Female
MH  - Fluorescein Angiography/*methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Predictive Value of Tests
MH  - Retina/pathology
MH  - Retinal Hemorrhage/diagnosis
MH  - Retinal Neovascularization/*diagnosis/etiology
MH  - Retinal Telangiectasis/*complications
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Acuity/physiology
EDAT- 2013/10/24 06:00
MHDA- 2014/09/03 06:00
CRDT- 2013/10/24 06:00
PHST- 2013/03/04 00:00 [received]
PHST- 2013/10/01 00:00 [accepted]
PHST- 2013/08/31 00:00 [revised]
PHST- 2013/10/24 06:00 [entrez]
PHST- 2013/10/24 06:00 [pubmed]
PHST- 2014/09/03 06:00 [medline]
AID - 10.1007/s00417-013-2491-4 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2014 Apr;252(4):549-53. doi: 
      10.1007/s00417-013-2491-4. Epub 2013 Oct 23.