PMID- 24150925
OWN - NLM
STAT- MEDLINE
DCOM- 20140513
LR  - 20131218
IS  - 1097-0142 (Electronic)
IS  - 0008-543X (Linking)
VI  - 120
IP  - 1
DP  - 2014 Jan 1
TI  - Risk of colorectal cancer and adenomas in the families of patients with adenomas: 
      a population-based study in Utah.
PG  - 35-42
LID - 10.1002/cncr.28227 [doi]
AB  - BACKGROUND: Guidelines recommend that individuals with a first-degree relative 
      (FDR) diagnosed with colorectal cancer (CRC) or advanced adenoma before age 60 
      years should undergo colonoscopy starting at age 40 years. The authors quantified 
      the risk of adenomas and CRC in FDRs, second-degree relatives (SDRs), and 
      third-degree relatives (TDRs) of patients diagnosed with adenomas and advanced 
      adenomas. METHODS: A population-based, retrospective, case-control study was 
      performed of residents of the state of Utah aged 50 years to 80 years who 
      underwent colonoscopy between 1995 and 2009 at Intermountain Healthcare or the 
      University of Utah. Controls were selected from the population of colonoscopy 
      patients who were free of adenomas or CRC and matched to each case based on sex 
      and birth year. Colonoscopy results were linked with cancer and pedigree 
      information from the Utah Population Database to investigate the familial 
      aggregation of adenomas and CRC using Cox regression analysis. The unit of 
      analysis was the relatives of cases and controls. RESULTS: Of 126,936 patients 
      who underwent colonoscopy, 43,189 had adenomas and 5563 had advanced adenomas and 
      defined the case population. An elevated risk of CRC was found in FDRs (relative 
      risk [RR], 1.35; 95% confidence interval [95% CI], 1.25-1.46), SDRs (RR, 1.15; 
      95% CI, 1.07-1.23) of adenoma cases, and in FDRs of advanced adenoma cases (RR, 
      1.68; 95% CI, 1.29-2.18) compared with controls. Approximately 10% of CRCs 
      diagnosed in relatives would have been missed if the current screening guidelines 
      were strictly adhered to. CONCLUSIONS: Relatives of colonoscopy patients with 
      adenomas and advanced adenomas appear to have a significantly elevated risk of 
      developing colorectal neoplasia. These data should be considered when 
      establishing CRC screening guidelines for individuals and their families.
CI  - (c) 2013 American Cancer Society.
FAU - Tuohy, Therese M F
AU  - Tuohy TM
AD  - Hereditary Gastrointestinal Cancer Registry, Huntsman Cancer Institute, 
      University of Utah, Salt Lake City, Utah.
FAU - Rowe, Kerry G
AU  - Rowe KG
FAU - Mineau, Geraldine P
AU  - Mineau GP
FAU - Pimentel, Richard
AU  - Pimentel R
FAU - Burt, Randall W
AU  - Burt RW
FAU - Samadder, N Jewel
AU  - Samadder NJ
LA  - eng
GR  - HHSN 261201000026C/PHS HHS/United States
GR  - P01-CA073992/CA/NCI NIH HHS/United States
GR  - P30CA042014/CA/NCI NIH HHS/United States
GR  - R01-CA040641/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20131021
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
CIN - Cancer. 2014 Jan 1;120(1):4-6. PMID: 24150996
MH  - Adenoma/epidemiology/*genetics/prevention & control
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Colonoscopy/*methods
MH  - Colorectal Neoplasms/epidemiology/*genetics/prevention & control
MH  - Early Detection of Cancer
MH  - Family Health
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Utah/epidemiology
OTO - NOTNLM
OT  - adenomatous polyps
OT  - colonoscopy
OT  - colorectal cancer
OT  - familial
EDAT- 2013/10/24 06:00
MHDA- 2014/05/14 06:00
CRDT- 2013/10/24 06:00
PHST- 2012/10/17 00:00 [received]
PHST- 2013/02/05 00:00 [revised]
PHST- 2013/02/26 00:00 [accepted]
PHST- 2013/10/24 06:00 [entrez]
PHST- 2013/10/24 06:00 [pubmed]
PHST- 2014/05/14 06:00 [medline]
AID - 10.1002/cncr.28227 [doi]
PST - ppublish
SO  - Cancer. 2014 Jan 1;120(1):35-42. doi: 10.1002/cncr.28227. Epub 2013 Oct 21.