PMID- 24151119
OWN - NLM
STAT- MEDLINE
DCOM- 20141215
LR  - 20151119
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 39
IP  - 5
DP  - 2014 May
TI  - Assessment of nonischemic fibrosis in hypertrophic cardiomyopathy: comparison of 
      gadopentetate dimeglumine and gadobenate dimeglumine for enhanced cardiovascular 
      magnetic resonance imaging.
PG  - 1153-60
LID - 10.1002/jmri.24264 [doi]
AB  - PURPOSE: To compare whether the higher relaxivity contrast agent gadobenate is 
      superior for the identification of nonischemic late gadolinium enhancement (LGE) 
      in hypertrophic cardiomyopathy (HCM) compared to standard relaxivity agents such 
      as gadopentetate. MATERIALS AND METHODS: Fifteen patients with HCM and positive 
      LGE based on routine cardiac magnetic resonance (CMR) with 0.2 mmol/kg 
      gadopentetate were enrolled. Each patient thereafter underwent a second enhanced 
      CMR exam with 0.2 mmol/kg gadobenate using the same CMR protocol. LGE was 
      assessed in a short axis stack acquired after contrast administration using an 
      inversion recovery gradient echo sequence. Two independent blinded readers 
      quantified LGE by manual planimetry. The signal intensities of injured 
      myocardium, remote myocardium, left ventricular cavity, and air were measured in 
      identical locations using anatomical landmarks and dedicated software. The 
      signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were calculated. 
      RESULTS: No adverse events related to contrast administration occurred. 
      Gadobenate dimeglumine showed a higher SNR of injured myocardium (45.4 +/- 24.0 vs. 
      31.1 +/- 16.6, P = 0.002) and a higher CNR between remote and injured myocardium 
      (37.6 +/- 25.0 vs. 26.5 +/- 17.6, P = 0.006) compared to gadopentetate dimeglumine. 
      The amount of LGE (based on the same postprocessing criteria and definitions) was 
      higher with gadobenate dimeglumine (12.7 +/- 8.5 g vs. 9.4 +/- 5.6 g, P = 0.005). 
      There was no difference in intra- and interobserver variability between 
      gadopentetate dimeglumine and gadobenate dimeglumine. CONCLUSION: CMR with the 
      high relaxivity contrast agent gadobenate dimeglumine reveals significantly more 
      tissue with LGE in patients with HCM.
CI  - Copyright (c) 2013 Wiley Periodicals, Inc.
FAU - Rudolph, Andre
AU  - Rudolph A
AD  - Working Group on Cardiovascular Magnetic Resonance, Experimental Clinical 
      Research Center, a joint cooperation between the Charite Medical Faculty and the 
      Max-Delbruck Center for Molecular Medicine, Berlin, Germany; HELIOS Klinikum 
      Berlin-Buch, Department of Cardiology and Nephrology, Berlin, Germany.
FAU - von Knobelsdorff-Brenkenhoff, Florian
AU  - von Knobelsdorff-Brenkenhoff F
FAU - Wassmuth, Ralf
AU  - Wassmuth R
FAU - Prothmann, Marcel
AU  - Prothmann M
FAU - Utz, Wolfgang
AU  - Utz W
FAU - Schulz-Menger, Jeanette
AU  - Schulz-Menger J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20131022
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 15G12L5X8K (gadobenic acid)
RN  - 6HG8UB2MUY (Meglumine)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Cardiomyopathy, Hypertrophic/*pathology
MH  - Contrast Media
MH  - Female
MH  - Fibrosis
MH  - *Gadolinium DTPA
MH  - Humans
MH  - Image Enhancement/methods
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Meglumine/*analogs & derivatives
MH  - Middle Aged
MH  - Myocardial Ischemia/pathology
MH  - Observer Variation
MH  - *Organometallic Compounds
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Stroke Volume
MH  - Young Adult
OTO - NOTNLM
OT  - gadobenate dimeglumine
OT  - hypertrophic cardiomyopathy
OT  - late gadolinium enhancement
EDAT- 2013/10/24 06:00
MHDA- 2014/12/17 06:00
CRDT- 2013/10/24 06:00
PHST- 2012/07/06 00:00 [received]
PHST- 2013/05/16 00:00 [accepted]
PHST- 2013/10/24 06:00 [entrez]
PHST- 2013/10/24 06:00 [pubmed]
PHST- 2014/12/17 06:00 [medline]
AID - 10.1002/jmri.24264 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2014 May;39(5):1153-60. doi: 10.1002/jmri.24264. Epub 2013 
      Oct 22.