PMID- 24151171
OWN - NLM
STAT- MEDLINE
DCOM- 20141030
LR  - 20141008
IS  - 1550-0594 (Print)
IS  - 1550-0594 (Linking)
VI  - 45
IP  - 3
DP  - 2014 Jul
TI  - Ifosfamide chemotherapy and nonconvulsive status epilepticus: case report and 
      review of the literature.
PG  - 222-5
AB  - We present a patient with peritoneal carcinosarcoma who was treated with the 
      alkylating agent ifosfamide and experienced a rapid decline in mental status. 
      Electroencephalogram (EEG) displayed generalized periodic epileptiform 
      discharges, which raised suspicion for nonconvulsive status epilepticus (NCSE). 
      Following administration of midazolam, the patient's clinical condition and EEG 
      improved. We review the 8 documented cases of ifosfamide-induced NCSE, and 
      demonstrate the similarity in clinical features when compared with ifosfamide 
      neurotoxicity that is not classified as NCSE. EEG findings suggesting an ictal 
      pattern are subtle and heterogeneous, but they are essential for a diagnosis. 
      Since it is unlikely that EEGs are uniformly obtained in instances of ifosfamide 
      neurotoxicity, many cases of NCSE may go unrecognized.
FAU - Taupin, Daniel
AU  - Taupin D
FAU - Racela, Rikki
AU  - Racela R
FAU - Friedman, Daniel
AU  - Friedman D
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Clin EEG Neurosci
JT  - Clinical EEG and neuroscience
JID - 101213033
RN  - R60L0SM5BC (Midazolam)
RN  - UM20QQM95Y (Ifosfamide)
SB  - IM
MH  - Carcinosarcoma/*drug therapy
MH  - Cerebral Cortex/drug effects/physiopathology
MH  - Diagnosis, Differential
MH  - Electroencephalography/*drug effects
MH  - Epilepsy, Generalized/*chemically induced/diagnosis/drug therapy
MH  - Evoked Potentials/drug effects
MH  - Fatal Outcome
MH  - Female
MH  - Humans
MH  - Ifosfamide/*adverse effects/*therapeutic use
MH  - Midazolam/therapeutic use
MH  - Middle Aged
MH  - Peritoneal Neoplasms/*drug therapy
MH  - *Signal Processing, Computer-Assisted
EDAT- 2013/10/24 06:00
MHDA- 2014/10/31 06:00
CRDT- 2013/10/24 06:00
PHST- 2013/10/24 06:00 [entrez]
PHST- 2013/10/24 06:00 [pubmed]
PHST- 2014/10/31 06:00 [medline]
AID - 1550059413500777 [pii]
AID - 10.1177/1550059413500777 [doi]
PST - ppublish
SO  - Clin EEG Neurosci. 2014 Jul;45(3):222-5. doi: 10.1177/1550059413500777.