PMID- 24152577
OWN - NLM
STAT- MEDLINE
DCOM- 20140707
LR  - 20211021
IS  - 1471-2490 (Electronic)
IS  - 1471-2490 (Linking)
VI  - 13
DP  - 2013 Oct 23
TI  - Changes of neuregulin-1 (NRG-1) expression in a rat model of overactive bladder 
      induced by partial urethral obstruction: is NRG-1 a new biomarker of overactive 
      bladder?
PG  - 54
LID - 10.1186/1471-2490-13-54 [doi]
AB  - BACKGROUND: To determine whether neuregulin-1(NRG-1) is a potential new biomarker 
      of overactive bladder (OAB) induced by partial urethral obstruction in a rat 
      model of OAB and to evaluate the urothelium as a therapeutic target of OAB. 
      METHODS: Female Sprague-Dawley rats were separated into three 20-animal groups: 
      normal, OAB, and 5-hydroxymethyl tolterodine (5-HMT)-treated OAB. In the OAB and 
      OAB + 5-HMT groups, the urethra of each animal was partially obstructed; the 
      OAB + 5-HMT group received intravenous 5-HMT for 3 weeks. At the conclusion of 
      the 5-HMT dosing, the rats in each group underwent cystometrography, and the 
      bladders were histologically evaluated. The expression of brain 
      derived-neurotrophic factor (BDNF) and NRG-1 were evaluated in the urothelium. 
      RESULTS: Compared with the control group, the OAB group showed a markedly 
      increased bladder weight and a significant decrease in the micturition interval 
      and volume; rats in the OAB + 5-HMT group showed decreased bladder weights and an 
      improved micturition interval and volume. BDNF and NRG-1 were expressed at 
      significantly higher levels in the OAB group, and were significantly reduced in 
      the OAB + 5-HMT group compared with the control group. CONCLUSIONS: The study 
      suggests that NRG-1 is a potential new biomarker of OAB; the urothelium might be 
      a therapeutic target for OAB treatment.
FAU - Jang, Hoon
AU  - Jang H
FAU - Han, Dong Seok
AU  - Han DS
FAU - Yuk, Seung Mo
AU  - Yuk SM
AD  - The Department of Urology, The Catholic University of Korea, DaeJeon St, Mary's 
      Hospital, Daeheung-dong, jug-gu, Daejeon, South Korea. doctor6@hanmail.net.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131023
PL  - England
TA  - BMC Urol
JT  - BMC urology
JID - 100968571
RN  - 0 (Biomarkers)
RN  - 0 (Neuregulin-1)
RN  - 0 (Nrg1 protein, rat)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Female
MH  - Neuregulin-1/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Urethral Obstruction/*complications/*metabolism
MH  - Urinary Bladder/*metabolism
MH  - Urinary Bladder, Overactive/*etiology/*metabolism
PMC - PMC4015862
EDAT- 2013/10/25 06:00
MHDA- 2014/07/08 06:00
PMCR- 2013/10/23
CRDT- 2013/10/25 06:00
PHST- 2013/08/08 00:00 [received]
PHST- 2013/10/22 00:00 [accepted]
PHST- 2013/10/25 06:00 [entrez]
PHST- 2013/10/25 06:00 [pubmed]
PHST- 2014/07/08 06:00 [medline]
PHST- 2013/10/23 00:00 [pmc-release]
AID - 1471-2490-13-54 [pii]
AID - 10.1186/1471-2490-13-54 [doi]
PST - epublish
SO  - BMC Urol. 2013 Oct 23;13:54. doi: 10.1186/1471-2490-13-54.