PMID- 24153331
OWN - NLM
STAT- MEDLINE
DCOM- 20140725
LR  - 20131127
IS  - 1440-1592 (Electronic)
IS  - 1323-8930 (Linking)
VI  - 62
IP  - 4
DP  - 2013 Dec
TI  - Determining minimal clinically important differences in Japanese cedar/cypress 
      pollinosis patients.
PG  - 487-93
LID - 10.2332/allergolint.13-OA-0570 [doi]
AB  - BACKGROUND: Statistically significant results of medical intervention trials are 
      not always clinically meaningful. We sought to estimate the minimal clinically 
      important difference (MCID) (the smallest change in a given endpoint that is 
      meaningful to a patient) during seasonal alteration of Japanese cedar/cypress 
      pollinosis (JCCP). METHODS: Results of a double-blinded, placebo-controlled trial 
      of JCCP patients conducted between 2008 and 2010 were analyzed using an 
      anchor-based method in which a face scale for Japanese rhinoconjunctivitis 
      quality-of-life questionnaire (JRQLQ) was set as an anchor. MICDs were calculated 
      as changes of average scores, including those for naso-ocular symptoms with 5 
      items in diary cards (T5SS), naso-ocular symptoms with 6 items (T6SS) and QOL 
      with 17 items on the JRQLQ when face scale scores either improved or deteriorated 
      by one point. RESULTS: In 2009 and 2010, 3,698 and 374, respectively, 
      grains/cm(2) of pollens were dispersed. The MCIDs for T5SS in 2009 and 2010 were 
      1.426 (0.285 per item) and 1.441 (0.288), respectively. The MCIDs for T6SS were 
      4.115 (0.686) and 3.183 (0.531) in 2009 and 2010, respectively. The MCIDs for QOL 
      were 10.469 (0.616) and 6.026 (0.354) in 2009 and 2010, respectively. 
      CONCLUSIONS: For T5SS in the diary, T6SS and QOL in JRQLQ, unit differences of 
      1.5 (0.3 per item), 3.6 (0.6) and 8.2 (0.5), respectively, were considered 
      clinically meaningful by JCCP patients. The MCID for symptoms recorded in the 
      diary was stable irrespective of the dispersed pollen level.
FAU - Higaki, Takaya
AU  - Higaki T
AD  - Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate 
      School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Okano, Mitsuhiro
AU  - Okano M
FAU - Kariya, Shin
AU  - Kariya S
FAU - Fujiwara, Tazuko
AU  - Fujiwara T
FAU - Haruna, Takenori
AU  - Haruna T
FAU - Hirai, Haruka
AU  - Hirai H
FAU - Murai, Aya
AU  - Murai A
FAU - Gotoh, Minoru
AU  - Gotoh M
FAU - Okubo, Kimihiro
AU  - Okubo K
FAU - Yonekura, Shuji
AU  - Yonekura S
FAU - Okamoto, Yoshitaka
AU  - Okamoto Y
FAU - Nishizaki, Kazunori
AU  - Nishizaki K
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20131025
PL  - England
TA  - Allergol Int
JT  - Allergology international : official journal of the Japanese Society of 
      Allergology
JID - 9616296
RN  - 0 (Allergens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Allergens/immunology
MH  - Cryptomeria/*adverse effects
MH  - Cupressus/*adverse effects
MH  - Female
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Pollen/adverse effects/immunology
MH  - *Quality of Life
MH  - Rhinitis, Allergic, Seasonal/immunology/*therapy
MH  - Self Report
MH  - *Sublingual Immunotherapy
MH  - Young Adult
EDAT- 2013/10/25 06:00
MHDA- 2014/07/26 06:00
CRDT- 2013/10/25 06:00
PHST- 2013/04/16 00:00 [received]
PHST- 2013/06/13 00:00 [accepted]
PHST- 2013/10/25 06:00 [entrez]
PHST- 2013/10/25 06:00 [pubmed]
PHST- 2014/07/26 06:00 [medline]
AID - S1323-8930(15)30167-2 [pii]
AID - 10.2332/allergolint.13-OA-0570 [doi]
PST - ppublish
SO  - Allergol Int. 2013 Dec;62(4):487-93. doi: 10.2332/allergolint.13-OA-0570. Epub 
      2013 Oct 25.