PMID- 24155701
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131024
LR  - 20220408
IS  - 1662-5153 (Print)
IS  - 1662-5153 (Electronic)
IS  - 1662-5153 (Linking)
VI  - 7
DP  - 2013
TI  - An investigation into "two hit" effects of BDNF deficiency and young-adult 
      cannabinoid receptor stimulation on prepulse inhibition regulation and memory in 
      mice.
PG  - 149
LID - 10.3389/fnbeh.2013.00149 [doi]
LID - 149
AB  - Reduced brain-derived neurotrophic factor (BDNF) signaling has been shown in the 
      frontal cortex and hippocampus in schizophrenia. The aim of the present study was 
      to investigate whether a BDNF deficit would modulate effects of chronic cannabis 
      intake, a well-described risk factor for schizophrenia development. BDNF 
      heterozygous mice (HET) and wild-type controls were chronically treated during 
      weeks 6, 7, and 8 of life with the cannabinoid receptor agonist, CP55,940 (CP). 
      After a 2-week delay, there were no CP-induced deficits in any of the groups in 
      short-term spatial memory in a Y-maze task or novel object recognition memory. 
      Baseline prepulse inhibition (PPI) was lower but average startle was increased in 
      BDNF HET compared to wild-type controls. Acute CP administration before the PPI 
      session caused a marked increase in PPI in male HET mice pre-treated with CP but 
      not in any of the other male groups. In females, there were small increases of 
      PPI in all groups upon acute CP administration. Acute CP administration 
      furthermore reduced startle and this effect was greater in HET mice irrespective 
      of chronic CP pre-treatment. Analysis of the levels of [(3)H]CP55,940 binding by 
      autoradiography revealed a significant increase in the nucleus accumbens of male 
      BDNF HET mice previously treated with CP but not in any of the other groups or in 
      the caudate nucleus. These results show that BDNF deficiency and chronic 
      young-adult cannabinoid receptor stimulation do not interact in this model on 
      learning and memory later in life. In contrast, male "two hit" mice, but not 
      females, were hypersensitive to the effect of acute CP on sensorimotor gating. 
      These effects may be related to a selective increase of [(3)H]CP55,940 binding in 
      the nucleus accumbens, reflecting up-regulation of CB1 receptor density in this 
      region. These data could be of relevance to our understanding of differential 
      "two hit" neurodevelopmental mechanisms in schizophrenia.
FAU - Klug, Maren
AU  - Klug M
AD  - Behavioural Neuroscience Laboratory, Mental Health Research Institute Melbourne, 
      VIC, Australia ; Department of Psychology, Swinburne University of Technology 
      Hawthorn, VIC, Australia.
FAU - van den Buuse, Maarten
AU  - van den Buuse M
LA  - eng
PT  - Journal Article
DEP - 20131021
PL  - Switzerland
TA  - Front Behav Neurosci
JT  - Frontiers in behavioral neuroscience
JID - 101477952
PMC - PMC3800788
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - cannabis
OT  - memory
OT  - mice
OT  - prepulse inhibition
OT  - schizophrenia
EDAT- 2013/10/25 06:00
MHDA- 2013/10/25 06:01
PMCR- 2013/01/01
CRDT- 2013/10/25 06:00
PHST- 2013/06/12 00:00 [received]
PHST- 2013/10/01 00:00 [accepted]
PHST- 2013/10/25 06:00 [entrez]
PHST- 2013/10/25 06:00 [pubmed]
PHST- 2013/10/25 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.3389/fnbeh.2013.00149 [doi]
PST - epublish
SO  - Front Behav Neurosci. 2013 Oct 21;7:149. doi: 10.3389/fnbeh.2013.00149. 
      eCollection 2013.