PMID- 24155868
OWN - NLM
STAT- MEDLINE
DCOM- 20140617
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 10
DP  - 2013
TI  - Prevention of neuromusculoskeletal frailty in slow-aging ames dwarf mice: 
      longitudinal investigation of interaction of longevity genes and caloric 
      restriction.
PG  - e72255
LID - 10.1371/journal.pone.0072255 [doi]
LID - e72255
AB  - Ames dwarf (Prop1 (df/df) ) mice are remarkably long-lived and exhibit many 
      characteristics of delayed aging and extended healthspan. Caloric restriction 
      (CR) has similar effects on healthspan and lifespan, and causes an extension of 
      longevity in Ames dwarf mice. Our study objective was to determine whether Ames 
      dwarfism or CR influence neuromusculoskeletal function in middle-aged (82 +/- 12 
      weeks old) or old (128 +/- 14 w.o.) mice. At the examined ages, strength was 
      improved by dwarfism, CR, and dwarfism plus CR in male mice; balance/ motor 
      coordination was improved by CR in old animals and in middle-aged females; and 
      agility/ motor coordination was improved by a combination of dwarfism and CR in 
      both genders of middle-aged mice and in old females. Therefore, extension of 
      longevity by congenital hypopituitarism is associated with improved maintenance 
      of the examined measures of strength, agility, and motor coordination, key 
      elements of frailty during human aging, into advanced age. This study serves as a 
      particularly important example of knowledge related to addressing 
      aging-associated diseases and disorders that results from studies in long-lived 
      mammals.
FAU - Arum, Oge
AU  - Arum O
AD  - Department of Internal Medicine, Southern Illinois University, School of 
      Medicine, Springfield, Illinois, United States of America.
FAU - Rasche, Zachary Andrew
AU  - Rasche ZA
FAU - Rickman, Dustin John
AU  - Rickman DJ
FAU - Bartke, Andrzej
AU  - Bartke A
LA  - eng
GR  - R01 AG019899/AG/NIA NIH HHS/United States
GR  - U19 AG023122/AG/NIA NIH HHS/United States
GR  - 3R01AG019899-07S1/AG/NIA NIH HHS/United States
GR  - AG19899/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20131014
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Body Weight
MH  - *Caloric Restriction
MH  - Dwarfism/*genetics
MH  - Female
MH  - Hand Strength/physiology
MH  - Humans
MH  - Longevity/*genetics
MH  - Male
MH  - Mice
MH  - Mice, Mutant Strains
MH  - Motor Activity/physiology
MH  - Musculoskeletal System/*innervation
MH  - Physical Fitness/*physiology
PMC - PMC3796515
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/10/25 06:00
MHDA- 2014/06/18 06:00
PMCR- 2013/10/14
CRDT- 2013/10/25 06:00
PHST- 2013/04/15 00:00 [received]
PHST- 2013/07/12 00:00 [accepted]
PHST- 2013/10/25 06:00 [entrez]
PHST- 2013/10/25 06:00 [pubmed]
PHST- 2014/06/18 06:00 [medline]
PHST- 2013/10/14 00:00 [pmc-release]
AID - PONE-D-13-15273 [pii]
AID - 10.1371/journal.pone.0072255 [doi]
PST - epublish
SO  - PLoS One. 2013 Oct 14;8(10):e72255. doi: 10.1371/journal.pone.0072255. 
      eCollection 2013.