PMID- 24157589
OWN - NLM
STAT- MEDLINE
DCOM- 20140127
LR  - 20131128
IS  - 1535-3699 (Electronic)
IS  - 1535-3699 (Linking)
VI  - 238
IP  - 12
DP  - 2013 Dec
TI  - The effects of caloric restriction against ethanol-induced oxidative and 
      nitrosative cardiotoxicity and plasma lipids in rats.
PG  - 1396-405
LID - 10.1177/1535370213506806 [doi]
AB  - Caloric restriction (CR) prevents or delays a wide range of aging-related 
      diseases possibly through alleviation of oxidative stress. The aim of our study 
      was to examine the effect of CR on oxidative and nitrosative cardiac damage in 
      rats, induced by acute ethanol intoxication. Male Wistar rats were divided into 
      following groups: control; calorie-restricted groups with intake of 60-70% 
      (CR60-70) and 40-50% of daily energy needs (CR40-50); ethanol-treated group (E); 
      calorie-restricted, ethanol-treated groups (CR60-70 + E, CR40-50 + E). Ethanol 
      was administered in five doses of 2 g/kg every 12 h, while the duration of CR was 
      five weeks before ethanol treatment. Malondialdehyde level was significantly 
      lower in CR60-70 + E and significantly higher in CR40-50 + E vs. control. Nitrite 
      and nitrate level was significantly higher in CR40-50 + E compared to control 
      group. Activity of total superoxide dismutase (SOD) and its isoenzyme, 
      copper/zinc-SOD (Cu/ZnSOD), was significantly higher in CR60-70 + E and lower in 
      CR40-50 + E vs. control. Activity of manganese-SOD (MnSOD), that is also SOD 
      isoenzyme, was significantly lower in  CR40-50 + E compared to control group. 
      Plasma content of sulfhydryl (SH) groups was significantly higher in CR60-70 
      group vs. control. Plasma concentration of total cholesterol, triacylglycerol, 
      low-density lipoproteins and high-density lipoproteins was significantly lower in 
      CR60-70 group compared to control values. Food restriction to 60-70% of daily 
      energy needs has a protective effect on acute ethanol-induced oxidative and 
      nitrosative cardiac damage, at least partly due to alleviation of ethanol-induced 
      decrease in SOD activity, while restriction to 40-50% of energy needs aggravates 
      lipid peroxidation and nitrosative stress.
FAU - Vucevic, Danijela
AU  - Vucevic D
AD  - Institute of Pathophysiology, "Ljubodrag Buba Mihailovic", Faculty of Medicine, 
      University of Belgrade, Belgrade 11000, Serbia.
FAU - Mladenovic, Dusan
AU  - Mladenovic D
FAU - Ninkovic, Milica
AU  - Ninkovic M
FAU - Aleksic, Vuk
AU  - Aleksic V
FAU - Stankovic, Milena N
AU  - Stankovic MN
FAU - Stankovic, Marija
AU  - Stankovic M
FAU - Jorgacevic, Bojan
AU  - Jorgacevic B
FAU - Vukicevic, Rada Jesic
AU  - Vukicevic RJ
FAU - Radosavljevic, Tatjana
AU  - Radosavljevic T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131024
PL  - Switzerland
TA  - Exp Biol Med (Maywood)
JT  - Experimental biology and medicine (Maywood, N.J.)
JID - 100973463
RN  - 0 (Lipids)
RN  - 0 (Nitrates)
RN  - 0 (Nitrites)
RN  - 0 (Sulfhydryl Compounds)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 3K9958V90M (Ethanol)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Animals
MH  - *Caloric Restriction
MH  - Dose-Response Relationship, Drug
MH  - Ethanol/*pharmacology
MH  - Heart/*drug effects
MH  - Lipid Peroxidation/drug effects
MH  - Lipids/*blood
MH  - Male
MH  - Malondialdehyde/analysis
MH  - Myocardium/chemistry/pathology
MH  - Nitrates/analysis
MH  - Nitric Oxide/analysis
MH  - Nitrites/analysis
MH  - Oxidative Stress/drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Sulfhydryl Compounds/blood
MH  - Superoxide Dismutase/metabolism
OTO - NOTNLM
OT  - Caloric restriction
OT  - ethanol
OT  - heart
OT  - oxidative stress
OT  - rats
EDAT- 2013/10/26 06:00
MHDA- 2014/01/28 06:00
CRDT- 2013/10/26 06:00
PHST- 2013/10/26 06:00 [entrez]
PHST- 2013/10/26 06:00 [pubmed]
PHST- 2014/01/28 06:00 [medline]
AID - 1535370213506806 [pii]
AID - 10.1177/1535370213506806 [doi]
PST - ppublish
SO  - Exp Biol Med (Maywood). 2013 Dec;238(12):1396-405. doi: 10.1177/1535370213506806. 
      Epub 2013 Oct 24.