PMID- 24158256
OWN - NLM
STAT- MEDLINE
DCOM- 20150219
LR  - 20140626
IS  - 1532-2092 (Electronic)
IS  - 1099-5129 (Linking)
VI  - 16
IP  - 7
DP  - 2014 Jul
TI  - Coronary artery reperfusion for ST elevation myocardial infarction is associated 
      with shorter cycle length ventricular tachycardia and fewer spontaneous 
      arrhythmias.
PG  - 1053-60
LID - 10.1093/europace/eut307 [doi]
AB  - AIMS: Ventricular tachycardia (VT) induction at electrophysiological (EP) study 
      early after ST elevation myocardial infarction (STEMI) has been a predictor of 
      spontaneous ventricular arrhythmia. Reperfusion therapy for STEMI may have 
      resulted in altered VT character. We attempted to determine differences in VT 
      cycle length (CL) and VT recurrence rates, in patients who received early and 
      late reperfusion treatment for STEMI. METHODS AND RESULTS: Of 180 consecutive 
      patients with left ventricular ejection fraction < 40%, 77 patients had positive 
      EP studies. Forty-nine patients receiving early reperfusion treatment (group 1, n 
      = 49) were compared with 28 patients who received late reperfusion (group 2; n = 
      28). Seventy-five patients had defibrillators implanted for primary prevention of 
      sudden death. Patients were followed for up to 6 years to assess long-term rates 
      of spontaneous ventricular tachyarrhythmia. Patients who received early 
      reperfusion demonstrated shorter CL inducible VT (231 +/- 43 ms vs. 252 +/- 56 ms; P 
      = 0.016). They also had fewer spontaneous arrhythmias (adjusted hazard ratio of 
      2.94, 95% confidence interval: 1.07-8.13; P = 0.03) with shorter CL spontaneous 
      VT (266 +/- 54 ms vs. 320 +/- 80 ms; P = 0.02) at 53 +/- 33 months. Ventricular 
      tachycardia CL was the only independent predictor of spontaneous arrhythmia or 
      sudden cardiac death (1.22, 1.07-1.47; P = 0.016). CONCLUSIONS: Patients 
      receiving early reperfusion for STEMI had faster inducible and spontaneous VT and 
      fewer spontaneous recurrences. This may be due to changes in the myocardial 
      substrate as a result of early coronary artery reperfusion.
CI  - Published on behalf of the European Society of Cardiology. All rights reserved. (c) 
      The Author 2013. For permissions please email: journals.permissions@oup.com.
FAU - Nalliah, Chrishan J
AU  - Nalliah CJ
AD  - Department of Cardiology, Westmead Hospital, Westmead, Sydney, NSW 2145, 
      Australia.
FAU - Zaman, Sarah
AU  - Zaman S
AD  - Department of Cardiology, Westmead Hospital, Westmead, Sydney, NSW 2145, 
      Australia.
FAU - Narayan, Arun
AU  - Narayan A
AD  - Department of Cardiology, Westmead Hospital, Westmead, Sydney, NSW 2145, 
      Australia.
FAU - Sullivan, Janice
AU  - Sullivan J
AD  - Department of Cardiology, Westmead Hospital, Westmead, Sydney, NSW 2145, 
      Australia.
FAU - Kovoor, Pramesh
AU  - Kovoor P
AD  - Department of Cardiology, Westmead Hospital, Westmead, Sydney, NSW 2145, 
      Australia pramesh.kovoor@sydney.edu.au.
LA  - eng
PT  - Journal Article
DEP - 20131024
PL  - England
TA  - Europace
JT  - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal 
      of the working groups on cardiac pacing, arrhythmias, and cardiac cellular 
      electrophysiology of the European Society of Cardiology
JID - 100883649
SB  - IM
MH  - Adult
MH  - Aged
MH  - Death, Sudden, Cardiac/etiology/prevention & control
MH  - Defibrillators, Implantable
MH  - Disease-Free Survival
MH  - Electric Countershock/instrumentation
MH  - Electrophysiologic Techniques, Cardiac
MH  - Female
MH  - Heart Conduction System/*physiopathology
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/complications/diagnosis/mortality/physiopathology/*therapy
MH  - *Myocardial Reperfusion/adverse effects/mortality
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Recurrence
MH  - Risk Factors
MH  - Tachycardia, Ventricular/diagnosis/*etiology/mortality/physiopathology/prevention 
      & control
MH  - Time Factors
MH  - Time-to-Treatment
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Acute myocardial infarction
OT  - Electrophysiology
OT  - ST elevation myocardial infarction
OT  - Ventricular tachycardia
EDAT- 2013/10/26 06:00
MHDA- 2015/02/20 06:00
CRDT- 2013/10/26 06:00
PHST- 2013/10/26 06:00 [entrez]
PHST- 2013/10/26 06:00 [pubmed]
PHST- 2015/02/20 06:00 [medline]
AID - eut307 [pii]
AID - 10.1093/europace/eut307 [doi]
PST - ppublish
SO  - Europace. 2014 Jul;16(7):1053-60. doi: 10.1093/europace/eut307. Epub 2013 Oct 24.