PMID- 24158279
OWN - NLM
STAT- MEDLINE
DCOM- 20141014
LR  - 20211021
IS  - 1435-1463 (Electronic)
IS  - 0300-9564 (Linking)
VI  - 121
IP  - 3
DP  - 2014
TI  - Serial repetitive transcranial magnetic stimulation (rTMS) decreases BDNF serum 
      levels in healthy male volunteers.
PG  - 307-13
LID - 10.1007/s00702-013-1102-1 [doi]
AB  - Although repetitive transcranial magnetic stimulation (rTMS) is established in 
      the treatment of depression, there is little knowledge about the underlying 
      molecular mechanisms. In the last decade, the neurotrophic hypothesis of 
      depression entailed a plethora of studies on the role of neurogenesis-associated 
      factors in affective disorders and rTMS treatment. In the present study, we 
      hypothesised a sham-controlled increase of peripheral brain-derived neurotrophic 
      factor (BDNF) levels following serial rTMS stimulations in healthy individuals. 
      We investigated the influence of a cycle of nine daily high-frequency (HF)-rTMS 
      (25 Hz) stimulations over the left dorsolateral prefrontal cortex (DLPFC) on 
      serum levels of BDNF in 44 young healthy male volunteers. BDNF serum 
      concentrations were measured at baseline, on day 5 and on day 10. Overall, the 
      statistical analyses showed that the active and sham group differed significantly 
      regarding their responses of BDNF serum levels. Contrary to our expectations, 
      there was a significant decrease of BDNF only during active treatment. Following 
      the treatment period, significantly lower BDNF serum levels were quantified in 
      the active group on day 10, when compared to the sham group. The participants' 
      smoking status affected this effect. Our results suggest that serial HF-rTMS 
      stimulations over the left DLPFC decrease serum BDNF levels in healthy male 
      volunteers. This provides further evidence for an involvement of BDNF in clinical 
      rTMS effects.
FAU - Schaller, Gerd
AU  - Schaller G
AD  - Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University of 
      Erlangen-Nuremberg, Schwabachanlage 6-10, 91054, Erlangen, Germany, 
      gerd.schaller@uk-erlangen.de.
FAU - Sperling, Wolfgang
AU  - Sperling W
FAU - Richter-Schmidinger, Tanja
AU  - Richter-Schmidinger T
FAU - Muhle, Christiane
AU  - Muhle C
FAU - Heberlein, Annemarie
AU  - Heberlein A
FAU - Maihofner, Christian
AU  - Maihofner C
FAU - Kornhuber, Johannes
AU  - Kornhuber J
FAU - Lenz, Bernd
AU  - Lenz B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131025
PL  - Austria
TA  - J Neural Transm (Vienna)
JT  - Journal of neural transmission (Vienna, Austria : 1996)
JID - 9702341
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Functional Laterality
MH  - Healthy Volunteers
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Prefrontal Cortex/*physiology
MH  - Psychiatric Status Rating Scales
MH  - Smoking/blood
MH  - Time Factors
MH  - *Transcranial Magnetic Stimulation
MH  - Young Adult
EDAT- 2013/10/26 06:00
MHDA- 2014/10/15 06:00
CRDT- 2013/10/26 06:00
PHST- 2013/07/09 00:00 [received]
PHST- 2013/10/09 00:00 [accepted]
PHST- 2013/10/26 06:00 [entrez]
PHST- 2013/10/26 06:00 [pubmed]
PHST- 2014/10/15 06:00 [medline]
AID - 10.1007/s00702-013-1102-1 [doi]
PST - ppublish
SO  - J Neural Transm (Vienna). 2014;121(3):307-13. doi: 10.1007/s00702-013-1102-1. 
      Epub 2013 Oct 25.