PMID- 24158372
OWN - NLM
STAT- MEDLINE
DCOM- 20140902
LR  - 20211021
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 252
IP  - 4
DP  - 2014 Apr
TI  - En face enhanced depth imaging optical coherence tomography features in adult 
      onset foveomacular vitelliform dystrophy.
PG  - 555-62
LID - 10.1007/s00417-013-2493-2 [doi]
AB  - BACKGROUND: Our purpose was to describe the different morphological features in 
      adult onset foveomacular vitelliform dystrophy (AOFVD), using en face enhanced 
      depth imaging (EDI) spectral-domain optical coherence tomography (SD-OCT). 
      METHODS: Thirty eyes of 22 consecutive patients presenting with diagnosis of 
      AOFVD were enrolled. Diagnosis of AOFVD was concluded based on fundus 
      examination, autofluorescence imaging, fluorescein angiography and SD-OCT. En 
      face OCT imaging was obtained with the Spectralis EDI SD-OCT; 97 inverted 
      sections (nine averaged B-scans per image) were acquired. RESULTS: On en face 
      OCT, vitelliform lesions appeared as regular concentric rings of different 
      reflectivity. From the periphery to center of the ring, we observed: (1) the 
      hypereflective ring representing the inner segment/ outer segment (IS/OS) 
      junction, which was continuous in 23 out of 30 eyes, and (2) a well-detectable 
      hyporeflective ring between the IS/OS junction and vitelliform material in 20 out 
      of 30 eyes; the innermost composant of the lesion was hypereflective, and it 
      corresponded to vitelliform material. In eight out of 30 eyes, a hyporeflective 
      "croissant"-shaped lesion with inferior concavity in the upper part of the 
      hyperreflective material was present. Hypereflective retinal pigment epithelium 
      (RPE) elevations or bumps were detected in 25 out of 30 eyes. These areas of 
      focal RPE thickening or bumps appeared to be intensely hypereflective on infrared 
      reflectance imaging. CONCLUSION: En face imaging of the retina helps visualizing 
      the distribution of vitelliform material in AOFVD. The sedimentation of 
      vitelliform lesions is characterized by a upper "croissant"-shaped 
      hypoflectivity. The bumps/thickening of RPE appeared as hypereflective lesions on 
      IR imaging.
FAU - Puche, Nathalie
AU  - Puche N
AD  - Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil, 
      University Paris Est Creteil, 40 Avenue de Verdun, 94000, Creteil, France.
FAU - Querques, Giuseppe
AU  - Querques G
FAU - Blanco-Garavito, Rocio
AU  - Blanco-Garavito R
FAU - Zerbib, Jennyfer
AU  - Zerbib J
FAU - Gherdaoui, Farah
AU  - Gherdaoui F
FAU - Tilleul, Julien
AU  - Tilleul J
FAU - Coscas, Florence
AU  - Coscas F
FAU - Glacet-Bernard, Agnes
AU  - Glacet-Bernard A
FAU - Souied, Eric H
AU  - Souied EH
LA  - eng
PT  - Journal Article
DEP - 20131026
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
MH  - Aged
MH  - Female
MH  - Fluorescein Angiography
MH  - Fovea Centralis/*pathology
MH  - Humans
MH  - Male
MH  - Retinal Pigment Epithelium/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Acuity/physiology
MH  - Vitelliform Macular Dystrophy/*diagnosis
EDAT- 2013/10/26 06:00
MHDA- 2014/09/03 06:00
CRDT- 2013/10/26 06:00
PHST- 2013/06/05 00:00 [received]
PHST- 2013/10/01 00:00 [accepted]
PHST- 2013/09/21 00:00 [revised]
PHST- 2013/10/26 06:00 [entrez]
PHST- 2013/10/26 06:00 [pubmed]
PHST- 2014/09/03 06:00 [medline]
AID - 10.1007/s00417-013-2493-2 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2014 Apr;252(4):555-62. doi: 
      10.1007/s00417-013-2493-2. Epub 2013 Oct 26.