PMID- 24158501
OWN - NLM
STAT- MEDLINE
DCOM- 20150219
LR  - 20211021
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 231
IP  - 5
DP  - 2014 Mar
TI  - MDMA enhances hippocampal-dependent learning and memory under restrictive 
      conditions, and modifies hippocampal spine density.
PG  - 863-74
LID - 10.1007/s00213-013-3304-5 [doi]
AB  - OBJECTIVES: Addictive drugs produce forms of structural plasticity in the nucleus 
      accumbens and prefrontal cortex. The aim of this study was to investigate the 
      impact of chronic MDMA exposure on pyramidal neurons in the CA1 region of 
      hippocampus and drug-related spatial learning and memory changes. METHODS AND 
      RESULTS: Adolescent rats were exposed to saline or MDMA in a regime that mimicked 
      chronic administration. One week later, when acquisition or reference memory was 
      evaluated in a standard Morris water maze (MWM), no differences were obtained 
      between groups. However, MDMA-exposed animals performed better when the MWM was 
      implemented under more difficult conditions. Animals of MDMA group were less 
      anxious and were more prepared to take risks, as in the open field test they 
      ventured more frequently into the central area. We have demonstrated that MDMA 
      caused an increase in brain-derived neurotrophic factor (BDNF) expression. When 
      spine density was evaluated, MDMA-treated rats presented a reduced density when 
      compared with saline, but overall, training increased the total number of spines, 
      concluding that in MDMA-group, training prevented a reduction in spine density or 
      induced its recovery. CONCLUSIONS: This study provides support for the conclusion 
      that binge administration of MDMA, known to be associated to neurotoxic damage of 
      hippocampal serotonergic terminals, increases BDNF expression and stimulates 
      synaptic plasticity when associated with training. In these conditions, 
      adolescent rats perform better in a more difficult water maze task under 
      restricted conditions of learning and memory. The effect on this task could be 
      modulated by other behavioural changes provoked by MDMA.
FAU - Abad, Sonia
AU  - Abad S
AD  - Department of Pharmacology and Therapeutic Chemistry (Pharmacology Section) and 
      Institute of Biomedicine (IBUB), University of Barcelona, Avda. Joan XXIII s/n, 
      Barcelona, 08028, Spain.
FAU - Fole, Alberto
AU  - Fole A
FAU - del Olmo, Nuria
AU  - del Olmo N
FAU - Pubill, David
AU  - Pubill D
FAU - Pallas, Merce
AU  - Pallas M
FAU - Junyent, Felix
AU  - Junyent F
FAU - Camarasa, Jorge
AU  - Camarasa J
FAU - Camins, Antonio
AU  - Camins A
FAU - Escubedo, Elena
AU  - Escubedo E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131026
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Body Temperature/drug effects
MH  - Body Weight/drug effects
MH  - CA1 Region, Hippocampal/cytology/*drug effects
MH  - Dendritic Spines/drug effects
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory/*drug effects
MH  - Memory Disorders/chemically induced
MH  - N-Methyl-3,4-methylenedioxyamphetamine/blood/*toxicity
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2013/10/26 06:00
MHDA- 2015/02/20 06:00
CRDT- 2013/10/26 06:00
PHST- 2013/06/18 00:00 [received]
PHST- 2013/09/23 00:00 [accepted]
PHST- 2013/10/26 06:00 [entrez]
PHST- 2013/10/26 06:00 [pubmed]
PHST- 2015/02/20 06:00 [medline]
AID - 10.1007/s00213-013-3304-5 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2014 Mar;231(5):863-74. doi: 
      10.1007/s00213-013-3304-5. Epub 2013 Oct 26.