PMID- 24159351
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20220408
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2013
DP  - 2013
TI  - Observational studies on evaluating the safety and adverse effects of traditional 
      chinese medicine.
PG  - 697893
LID - 10.1155/2013/697893 [doi]
LID - 697893
AB  - Background. This study aims to share our experiences when carrying out 
      observational studies of traditional Chinese medicine (TCM). Methods. We have 
      proactively monitored the safety profiles of Duhuo Jisheng Tang (DJT), Suan Zao 
      Ren Tang (SZRT), and TMN-1. A list of adverse events (AEs), complete blood 
      counts, and liver and kidney function tests were obtained from the participants 
      during their scheduled hospital visits. Retrospective observational studies were 
      conducted based on the reimbursement database of the National Health Insurance 
      system, Taiwan, to explore the relationship between the use of TCM that have been 
      adulterated by aristolochic acid and the risk from both nephrotoxins and 
      carcinogens. Results. A total of 221, 287, and 203 AEs were detected after SZRT, 
      DJT, and TMN-1 had been taken, respectively. Dizziness, headache, stomach ache, 
      and diarrhea were judged to be probably related to SZRT treatment. Retrospective 
      observational studies found an association between the consumption of 
      aristolochic acid-containing Chinese formulae such as Mu Tong and an increased 
      risk of CKD, ESRD, and urinary tract cancer. Conclusion. Prospective and 
      retrospective observational studies seem to have specific advantages when 
      investigating the safety and adverse effects of TCM therapies, as well as 
      possibly other alternative/complementary therapies.
FAU - Lai, Jung-Nein
AU  - Lai JN
AD  - Institute of Traditional Medicine, School of Medicine, National Yang-Ming 
      University, Taipei City 112, Taiwan ; Department of Chinese Medicine, Taipei City 
      Hospital, Yangming Branch, Taipei City 111, Taiwan.
FAU - Tang, Jin-Ling
AU  - Tang JL
FAU - Wang, Jung-Der
AU  - Wang JD
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130914
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC3789390
EDAT- 2013/10/26 06:00
MHDA- 2013/10/26 06:01
PMCR- 2013/09/14
CRDT- 2013/10/26 06:00
PHST- 2013/04/07 00:00 [received]
PHST- 2013/06/23 00:00 [revised]
PHST- 2013/08/10 00:00 [accepted]
PHST- 2013/10/26 06:00 [entrez]
PHST- 2013/10/26 06:00 [pubmed]
PHST- 2013/10/26 06:01 [medline]
PHST- 2013/09/14 00:00 [pmc-release]
AID - 10.1155/2013/697893 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2013;2013:697893. doi: 10.1155/2013/697893. 
      Epub 2013 Sep 14.