PMID- 24159370
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140729
LR  - 20211021
IS  - 2040-1752 (Electronic)
IS  - 2040-1744 (Print)
IS  - 2040-1744 (Linking)
VI  - 4
IP  - 5
DP  - 2013 Oct
TI  - Ovine fetal renal development impacted by multiple fetuses and uterine space 
      restriction.
PG  - 411-20
LID - 10.1017/S2040174413000329 [doi]
AB  - Intrauterine growth restriction (IUGR) from uteroplacental dysfunction causes 
      impaired nephrogenesis and ultimately hypertension, but it is unknown whether 
      IUGR caused by insufficient space for placental development seen in uterine 
      anomalies and/or multifetal gestation exerts the same effects. Fetal renal 
      development and metabolism were studied in an ovine space-restriction model by 
      combining unilateral horn surgical ligation and/or multifetal gestation. Reduced 
      placental attachment sites and placental weight per fetus defined 
      space-restricted (USR) v. control nonrestricted (NSR) fetuses. Space-restricted 
      fetuses exhibited evidence for decreased plasma volume, with higher hematocrit 
      and plasma albumin at gestational day (GD) 120, followed by lower blood pO2, and 
      higher osmolarity and creatinine at GD130, P < 0.05 for all. By combining 
      treatments, fetal kidney weight relative to fetal weight was inversely related to 
      both fetal weight and plasma creatinine levels, P < 0.05 for both. At GD130, 
      space-restricted fetal kidney weights, cortical depths and glomerular generations 
      were decreased, P < 0.05 for all. Space-restricted kidneys underwent an adaptive 
      response by prolonging active nephrogenesis and increasing maculae densa number, 
      P < 0.05 for both. The major renal adaptations in space-restricted IUGR fetuses 
      included immaturity in both development and endocrine function, with evidence for 
      impaired renal excretory function.
FAU - Meyer-Gesch, K M
AU  - Meyer-Gesch KM
AD  - 1 Departments of Pediatrics, University of Wisconsin, Madison, WI 53715, USA.
FAU - Sun, M Y
AU  - Sun MY
AD  - 1 Departments of Pediatrics, University of Wisconsin, Madison, WI 53715, USA.
FAU - Koch, J M
AU  - Koch JM
AD  - 3 Obstetrics and Gynecology, Perinatal Research Laboratory, University of 
      Wisconsin, Madison, WI 53715, USA.
FAU - Ramadoss, J
AU  - Ramadoss J
AD  - 3 Obstetrics and Gynecology, Perinatal Research Laboratory, University of 
      Wisconsin, Madison, WI 53715, USA.
FAU - Blohowiak, S E
AU  - Blohowiak SE
AD  - 1 Departments of Pediatrics, University of Wisconsin, Madison, WI 53715, USA.
FAU - Magness, R R
AU  - Magness RR
AD  - 1 Departments of Pediatrics, University of Wisconsin, Madison, WI 53715, USA.
FAU - Kling, P J
AU  - Kling PJ
AD  - 1 Departments of Pediatrics, University of Wisconsin, Madison, WI 53715, USA.
LA  - eng
GR  - P01 HD038843/HD/NICHD NIH HHS/United States
GR  - R01 HL049210/HL/NHLBI NIH HHS/United States
GR  - R01 HL087144/HL/NHLBI NIH HHS/United States
GR  - R01 HL117341/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - J Dev Orig Health Dis
JT  - Journal of developmental origins of health and disease
JID - 101517692
PMC - PMC3805357
MID - NIHMS491571
COIS- STATEMENT OF INTEREST None.
EDAT- 2013/10/26 06:00
MHDA- 2013/10/26 06:01
PMCR- 2013/10/22
CRDT- 2013/10/26 06:00
PHST- 2013/10/26 06:00 [entrez]
PHST- 2013/10/26 06:00 [pubmed]
PHST- 2013/10/26 06:01 [medline]
PHST- 2013/10/22 00:00 [pmc-release]
AID - S2040174413000329 [pii]
AID - 10.1017/S2040174413000329 [doi]
PST - ppublish
SO  - J Dev Orig Health Dis. 2013 Oct;4(5):411-20. doi: 10.1017/S2040174413000329.