PMID- 24159780
OWN - NLM
STAT- MEDLINE
DCOM- 20140206
LR  - 20181202
IS  - 0023-2149 (Print)
IS  - 0023-2149 (Linking)
VI  - 91
IP  - 5
DP  - 2013
TI  - [Drug interaction of proton pump inhibitors and clopidogrel taken together].
PG  - 15-21
AB  - Current clinical practice lays special emphasis on drug interactions. High rates 
      of cardiovascular morbidity and acid-dependent diseases dictates the necessity of 
      antiaggregation and antisecretory therapy. The former uses a variety of medicines 
      with acetylsalicylic acid (ASA) and clopidogrel being the most popular ones. 
      Therapy using drugs with different mechanisms of action on the thrombocytic 
      component of homeostasis appears to be especially promising as having synergic 
      antiplatelet effect. The most common variant of antiplatelet therapy is a 
      combination of ASA and clopidogrel usually referred to as double antiplatelet 
      therapy (DAP). Current consensus recommends intake of proton pump inhibitors 
      (PPI) during DAP to reduce the risk of gastrointestinal complications. However, 
      recent studies showed that this approach is fraught with severe cardiovascular 
      disorders, such as myocardial infarction, stroke, unstable angina, necessity of 
      repeat coronary interventions, and coronary death. Hence, the importance of 
      differential application of PPI in patients treated with ASA and clopidogrel. A 
      comprehensive review of this problem is presented along with results of 
      investigations of PPI action on clinical outcome of clopidrogel therapy.
FAU - Maev, I V
AU  - Maev IV
FAU - Samsonov, A A
AU  - Samsonov AA
FAU - Godilo-Godlevskii, V A
AU  - Godilo-Godlevskii VA
FAU - Andreev, D N
AU  - Andreev DN
FAU - Dicheva, D T
AU  - Dicheva DT
LA  - rus
PT  - Journal Article
PT  - Review
PL  - Russia (Federation)
TA  - Klin Med (Mosk)
JT  - Klinicheskaia meditsina
JID - 2985204R
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 0 (Proton Pump Inhibitors)
RN  - A74586SNO7 (Clopidogrel)
RN  - OM90ZUW7M1 (Ticlopidine)
SB  - IM
MH  - Cardiovascular Diseases/chemically induced/*drug therapy
MH  - Clopidogrel
MH  - *Drug Interactions
MH  - Drug Therapy, Combination/*adverse effects
MH  - Humans
MH  - Platelet Aggregation Inhibitors/administration & dosage/*adverse effects
MH  - Proton Pump Inhibitors/administration & dosage/*adverse effects
MH  - Ticlopidine/administration & dosage/adverse effects/*analogs & derivatives
EDAT- 2013/10/29 06:00
MHDA- 2014/02/07 06:00
CRDT- 2013/10/29 06:00
PHST- 2013/10/29 06:00 [entrez]
PHST- 2013/10/29 06:00 [pubmed]
PHST- 2014/02/07 06:00 [medline]
PST - ppublish
SO  - Klin Med (Mosk). 2013;91(5):15-21.