PMID- 24160849
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20190116
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 55
IP  - 8
DP  - 2014 Aug
TI  - Large B-cell lymphomas in adolescents and young adults in comparison to adult 
      patients: a matched-control analysis in 55 patients.
PG  - 1849-53
LID - 10.3109/10428194.2013.858814 [doi]
AB  - The aim of our study was to assess whether large B-cell lymphoma (LBCL) in 
      adolescents and young adults (AYA) should be considered as a clinocopathological 
      entity, and to evaluate the prognostic value of age. Fifty-five patients aged > 
      15-30 years were fully matched to 365 adult patients aged 31-65 years. We found a 
      high incidence of primary mediastinal thymic LBCL subtype (33% vs. 5%), while 
      histological transformation was rare (2% vs. 14%). LBCL in AYA presented with a 
      bulky mediastinal mass (51% vs. 21%), and the lactate dehydrogenase (LDH) value 
      was significantly higher (73% vs. 54%). The complete response rate to 
      chemotherapy was similar in the two groups. Five-year overall survival (OS) and 
      event-free survival (EFS) of AYA were 73% and 68%, respectively. The 
      matched-control analysis showed no difference for either OS or EFS. LBCL in AYA 
      presents with some critical features which differ from those of older adults. 
      However, the outcome is equivalent to that observed in older patients.
FAU - Coso, Diane
AU  - Coso D
AD  - Department of Hematology, Institut J. Paoli-I. Calmettes, Universite de la 
      Mediterranee , Marseille , France.
FAU - Garciaz, Sylvain
AU  - Garciaz S
FAU - Esterni, Benjamin
AU  - Esterni B
FAU - Broussais-Guillaumot, Florence
AU  - Broussais-Guillaumot F
FAU - Ivanov, Vadim
AU  - Ivanov V
FAU - Aurran-Schleinitz, Therese
AU  - Aurran-Schleinitz T
FAU - Schiano, Jean-Marc
AU  - Schiano JM
FAU - Stoppa, Anne-Marie
AU  - Stoppa AM
FAU - Chetaille, Bruno
AU  - Chetaille B
FAU - Blaise, Didier
AU  - Blaise D
FAU - Vey, Norbert
AU  - Vey N
FAU - Bouabdallah, Reda
AU  - Bouabdallah R
LA  - eng
PT  - Journal Article
DEP - 20140214
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Lymphoma, Large B-Cell, Diffuse/*diagnosis/mortality/*therapy
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Large cell lymphoma
OT  - adolescents
OT  - young adults
EDAT- 2013/10/29 06:00
MHDA- 2015/03/31 06:00
CRDT- 2013/10/29 06:00
PHST- 2013/10/29 06:00 [entrez]
PHST- 2013/10/29 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - 10.3109/10428194.2013.858814 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2014 Aug;55(8):1849-53. doi: 10.3109/10428194.2013.858814. Epub 
      2014 Feb 14.