PMID- 24161446
OWN - NLM
STAT- MEDLINE
DCOM- 20140127
LR  - 20220321
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 62
DP  - 2014 Jan
TI  - Early life phthalate exposure and atopic disorders in children: a prospective 
      birth cohort study.
PG  - 48-54
LID - S0160-4120(13)00195-5 [pii]
LID - 10.1016/j.envint.2013.09.002 [doi]
AB  - The role of phthalate exposure at different stages in the immune system and 
      atopic disorders is not well-known. This study aims to evaluate the effects of 
      prenatal and postnatal phthalate exposures on immunoglobulin E (IgE) levels and 
      atopic dermatitis (AD) in children by objective biomarkers. We conducted a 
      prospective Taiwan Birth Panel cohort study with 483 mother/infant pairs. 
      Finally, 161 urine specimens at 3rd trimester of pregnancy, 219 urine specimens 
      from children at age 2, and 192 urine specimens at age 5 were analyzed after 
      excluding missing data and loss to follow-up. Urine monoethyl phthalate (MEP), 
      monobutyl phthalate (MBP), monobenzyl phthalate (MBzP), and mono-(2-ethylhexyl) 
      phthalate (MEHP) at 3rd trimester of pregnancy and at ages 2 and 5 were measured 
      by ultra-performance liquid chromatography coupled with tandem mass spectrometry. 
      At ages 2 and 5, information on the development of AD and serum total IgE was 
      collected. The association between urine phthalate metabolite levels at different 
      stages and serum IgE and AD was evaluated by multivariate linear regression and 
      logistic regression. Urine phthalate metabolite levels were higher at age 2 than 
      those at pregnancy and age 5. At each period, urine MBP levels were higher than 
      MEP, MEHP, and MBzP. MEHP levels at age 2 positively correlated with serum IgE 
      levels (per ln-unit: beta=0.191, p=0.02). Analyses stratified by gender revealed 
      that MEHP levels positively correlated with serum IgE levels only in boys (per 
      ln-unit: beta=0.256, p=0.03). When dividing into quartiles, urine MBzP levels at age 
      2 had a significant association with AD. We found no statistically significant 
      association of other phthalate metabolites with IgE and AD. Early life phthalate 
      exposure may increase the risk of allergic sensitization and atopic disorders.
CI  - (c) 2013.
FAU - Wang, I-Jen
AU  - Wang IJ
AD  - Department of Pediatrics, Taipei Hospital, Ministry of Health and Welfare, 
      Taipei, Taiwan; China Medical University, Taichung, Taiwan; College of Medicine, 
      National Yang-Ming University, Taipei, Taiwan.
FAU - Lin, Ching-Chun
AU  - Lin CC
FAU - Lin, Yen-Ju
AU  - Lin YJ
FAU - Hsieh, Wu-Shiun
AU  - Hsieh WS
FAU - Chen, Pau-Chung
AU  - Chen PC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131024
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Biomarkers)
RN  - 0 (Phthalic Acids)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Biomarkers/blood
MH  - Child
MH  - Cohort Studies
MH  - Dermatitis, Atopic/*epidemiology
MH  - *Environmental Exposure
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Infant
MH  - Male
MH  - Maternal Exposure
MH  - Phthalic Acids/metabolism/*urine
MH  - Pregnancy
MH  - Pregnancy Trimester, Third
MH  - Prospective Studies
MH  - Sex Factors
MH  - Taiwan/epidemiology
OTO - NOTNLM
OT  - AD
OT  - Atopic dermatitis
OT  - BBzP
OT  - Cohort study
OT  - DBP
OT  - DEHP
OT  - DEP
OT  - GM
OT  - IgE
OT  - MBP
OT  - MBzP
OT  - MEHP
OT  - MEP
OT  - atopic dermatitis
OT  - butyl benzyl phthalate
OT  - di(2-ethylhexyl) phthalate
OT  - dibutyl phthalate
OT  - diethylphthalate
OT  - geometric mean
OT  - immunoglobulin E
OT  - mono(2-ethylhexyl) phthalate
OT  - monobenzyl phthalate
OT  - monobutyl phthalate
OT  - monoethyl phthalate
EDAT- 2013/10/29 06:00
MHDA- 2014/01/28 06:00
CRDT- 2013/10/29 06:00
PHST- 2012/12/01 00:00 [received]
PHST- 2013/09/03 00:00 [revised]
PHST- 2013/09/03 00:00 [accepted]
PHST- 2013/10/29 06:00 [entrez]
PHST- 2013/10/29 06:00 [pubmed]
PHST- 2014/01/28 06:00 [medline]
AID - S0160-4120(13)00195-5 [pii]
AID - 10.1016/j.envint.2013.09.002 [doi]
PST - ppublish
SO  - Environ Int. 2014 Jan;62:48-54. doi: 10.1016/j.envint.2013.09.002. Epub 2013 Oct 
      24.