PMID- 24161824
OWN - NLM
STAT- MEDLINE
DCOM- 20140815
LR  - 20211021
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1542
DP  - 2014 Jan 13
TI  - Prolyl carboxypeptidase mRNA expression in the mouse brain.
PG  - 85-92
LID - S0006-8993(13)01422-4 [pii]
LID - 10.1016/j.brainres.2013.10.031 [doi]
AB  - Prolyl carboxypeptidase (PRCP), a serine protease, is widely expressed in the 
      body including liver, lung, kidney and brain, with a variety of known substrates 
      such as plasma prekallikrein, bradykinin, angiotensins II and III, and alpha-MSH, 
      suggesting its role in the processing of tissue-specific substrates. In the 
      brain, PRCP has been shown to inactivate hypothalamic alpha-MSH, thus modulating 
      melanocortin signaling in the control of energy metabolism. While its expression 
      pattern has been reported in the hypothalamus, little is known on the 
      distribution of PRCP throughout the mouse brain. This study was undertaken to 
      determine PRCP expression in the mouse brain. Radioactive in situ hybridization 
      was performed to determine endogenous PRCP mRNA expression. In addition, using a 
      gene-trap mouse model for PRCP deletion, X-gal staining was performed to further 
      determine PRCP distribution. Results from both approaches showed that PRCP gene 
      is broadly expressed in the brain.
CI  - (c) 2013 Published by Elsevier B.V.
FAU - Jeong, Jin Kwon
AU  - Jeong JK
AD  - Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale 
      University School of Medicine, New Haven, CT, USA; Department of Ob/Gyn & 
      Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA.
FAU - Diano, Sabrina
AU  - Diano S
AD  - Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale 
      University School of Medicine, New Haven, CT, USA; Department of Ob/Gyn & 
      Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA; 
      Department of Neurobiology, Yale University School of Medicine, New Haven, CT, 
      USA; Section of Comparative Medicine, Yale University School of Medicine, New 
      Haven, CT, USA. Electronic address: sabrina.diano@yale.edu.
LA  - eng
GR  - R01 DK084065/DK/NIDDK NIH HHS/United States
GR  - DK084065/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20131024
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Galactosides)
RN  - 0 (Indoles)
RN  - 0 (RNA, Messenger)
RN  - EC 3.4.- (Carboxypeptidases)
RN  - V595OG374W (5-bromo-4-chloro-3-indolyl beta-galactoside)
SB  - IM
MH  - Animals
MH  - Brain/*enzymology
MH  - Carboxypeptidases/*genetics/*metabolism
MH  - Galactosides/metabolism
MH  - Gene Expression
MH  - Indoles/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - RNA, Messenger/*metabolism
PMC - PMC3893042
MID - NIHMS534501
OTO - NOTNLM
OT  - 3v
OT  - 4v
OT  - ARC
OT  - Amyg
OT  - BLA
OT  - Brain
OT  - CA
OT  - Cb
OT  - Central Nervous System
OT  - Cing Ctx
OT  - D3v
OT  - DG
OT  - DMH
OT  - DMV
OT  - Distribution
OT  - ECu
OT  - Gi
OT  - HP
OT  - HYP
OT  - LH
OT  - LPO
OT  - LSN
OT  - LVe
OT  - Lv
OT  - MC3R
OT  - MC4R
OT  - MHb
OT  - MM
OT  - MPO
OT  - MVe
OT  - NTS
OT  - PRCP: CNS
OT  - PV
OT  - PVN
OT  - Pir Ctx
OT  - Pir ctx
OT  - Pn
OT  - PnO
OT  - Pr
OT  - Prolyl carboxypeptidase
OT  - RtTg
OT  - SN
OT  - SO
OT  - Sp5
OT  - Thal
OT  - Thalamus
OT  - VM
OT  - VMH
OT  - VTA
OT  - Xi
OT  - ZI
OT  - ac
OT  - amygdala
OT  - anterior commissure
OT  - arcuate nucleus of the hypothalamus
OT  - basolateral amygdala
OT  - cerebellum
OT  - cerebral aqueduct
OT  - cingulate cortex
OT  - dentate gyrus
OT  - dorsal motor nucleus of the vagus
OT  - dorsal third ventricle
OT  - dorsomedial hypothalamic nucleus
OT  - ec
OT  - external capsule
OT  - external cuneate nucleus
OT  - f
OT  - fornix
OT  - fourth ventricle
OT  - gigantocellular reticular nucleus
OT  - hippocampus
OT  - hypothalamus
OT  - lateral hypothalamus
OT  - lateral preoptic area
OT  - lateral septal nucleus
OT  - lateral ventricle
OT  - lateral vestibular nucleus
OT  - mammillary body
OT  - medial habenular nucleus
OT  - medial preoptic area
OT  - medial preoptic nucleus
OT  - medial vestibular nucleus
OT  - melanocortin 3 receptor
OT  - melanocortin 4 receptor
OT  - nucleus of solitarius tract
OT  - paraventricular nucleus of hypothalamus
OT  - paraventricular nucleus of the thalamus
OT  - piriform cortex
OT  - pontine nuclei
OT  - pontine reticular nucleus
OT  - prepositus nucleus
OT  - reticulotegmental nucleus of the pons
OT  - spinal trigeminal nucleus
OT  - substantia nigra
OT  - supraoptic nucleus
OT  - third ventricle
OT  - ventral tegmental area
OT  - ventromedial nucleus of the hypothalamus
OT  - ventromedial nucleus of the thalamus
OT  - ventrotegmental area
OT  - xiphoid thalamic nucleus
OT  - zona incerta
OT  - alpha-MSH: alpha-melanocyte stimulating hormone
EDAT- 2013/10/29 06:00
MHDA- 2014/08/16 06:00
PMCR- 2015/01/13
CRDT- 2013/10/29 06:00
PHST- 2013/09/20 00:00 [received]
PHST- 2013/10/16 00:00 [revised]
PHST- 2013/10/17 00:00 [accepted]
PHST- 2013/10/29 06:00 [entrez]
PHST- 2013/10/29 06:00 [pubmed]
PHST- 2014/08/16 06:00 [medline]
PHST- 2015/01/13 00:00 [pmc-release]
AID - S0006-8993(13)01422-4 [pii]
AID - 10.1016/j.brainres.2013.10.031 [doi]
PST - ppublish
SO  - Brain Res. 2014 Jan 13;1542:85-92. doi: 10.1016/j.brainres.2013.10.031. Epub 2013 
      Oct 24.