PMID- 24164734
OWN - NLM
STAT- MEDLINE
DCOM- 20141021
LR  - 20220409
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 39
IP  - 2
DP  - 2014
TI  - Acute aerobic exercise increases brain-derived neurotrophic factor levels in 
      elderly with Alzheimer's disease.
PG  - 401-8
LID - 10.3233/JAD-131073 [doi]
AB  - Studies indicate the involvement of brain-derived neurotrophic factor (BDNF) in 
      the pathogenesis of Alzheimer's disease (AD). Decreased BDNF levels may 
      constitute a lack of trophic support and contribute to cognitive impairment in 
      AD. The benefits of acute and chronic physical exercise on BDNF levels are 
      well-documented in humans, however, exercise effects on BDNF levels have not been 
      analyzed in older adults with AD. The aim of this study was to investigate the 
      effects of acute aerobic exercise on BDNF levels in older adults with AD and to 
      verify associations among BDNF levels, aerobic fitness, and level of physical 
      activity. Using a controlled design, twenty-one patients with AD (76.3 +/- 6.2 
      years) and eighteen healthy older adults (74.6 +/- 4.7 years) completed an acute 
      aerobic exercise. The outcomes included measures of BDNF plasma levels, aerobic 
      fitness (treadmill grade, time to exhaustion, VO2, and maximal lactate) and level 
      of physical activity (Baecke Questionnaire Modified for the Elderly). The 
      independent t-test shows differences between groups with respect to the BDNF 
      plasma levels at baseline (p = 0.04; t = 4.53; df = 37). In two-way ANOVA, a 
      significant effect of time was found (p = 0.001; F = 13.63; df = 37), the aerobic 
      exercise significantly increased BDNF plasma levels in AD patients and healthy 
      controls. A significant correlation (p = 0.04; r = 0.33) was found between BDNF 
      levels and the level of physical activity. The results of our study suggest that 
      aerobic exercise increases BDNF plasma levels in patients with AD and healthy 
      controls. In addition to that, BDNF levels had association with level of physical 
      activity.
FAU - Coelho, Flavia Gomes de Melo
AU  - Coelho FG
AD  - Institute of Biosciences, UNESP, University Estadual Paulista, Physical Activity 
      and Aging Lab (LAFE), Rio Claro, SP, Brazil.
FAU - Vital, Thays Martins
AU  - Vital TM
AD  - Institute of Biosciences, UNESP, University Estadual Paulista, Physical Activity 
      and Aging Lab (LAFE), Rio Claro, SP, Brazil.
FAU - Stein, Angelica Miki
AU  - Stein AM
AD  - Institute of Biosciences, UNESP, University Estadual Paulista, Physical Activity 
      and Aging Lab (LAFE), Rio Claro, SP, Brazil.
FAU - Arantes, Franciel Jose
AU  - Arantes FJ
AD  - Institute of Biosciences, UNESP, University Estadual Paulista, Physical Activity 
      and Aging Lab (LAFE), Rio Claro, SP, Brazil.
FAU - Rueda, Andre Veloso
AU  - Rueda AV
AD  - Institute of Biomedical Sciences, USP, University of Sao Paulo, Department of 
      Pharmacology, Laboratory of Neurochemistry and Behavioral Pharmacology, Sao 
      Paulo, SP, Brazil.
FAU - Camarini, Rosana
AU  - Camarini R
AD  - Institute of Biomedical Sciences, USP, University of Sao Paulo, Department of 
      Pharmacology, Laboratory of Neurochemistry and Behavioral Pharmacology, Sao 
      Paulo, SP, Brazil.
FAU - Teodorov, Elizabeth
AU  - Teodorov E
AD  - Center of Mathematics, Computing and Cognition, UFABC, University Federal of ABC, 
      Santo Andre, SP, Brazil.
FAU - Santos-Galduroz, Ruth Ferreira
AU  - Santos-Galduroz RF
AD  - Institute of Biosciences, UNESP, University Estadual Paulista, Physical Activity 
      and Aging Lab (LAFE), Rio Claro, SP, Brazil Center of Mathematics, Computing and 
      Cognition, UFABC, University Federal of ABC, Santo Andre, SP, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*blood/complications/diagnosis
MH  - Analysis of Variance
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cognition Disorders/blood/diagnosis/etiology
MH  - Exercise/*physiology
MH  - Humans
MH  - Physical Fitness
MH  - Psychiatric Status Rating Scales
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - Aerobic exercise
OT  - Alzheimer's disease
OT  - brain-derived neurotrophic factor
OT  - neurotrophic factors
OT  - physical activity
EDAT- 2013/10/30 06:00
MHDA- 2014/10/22 06:00
CRDT- 2013/10/30 06:00
PHST- 2013/10/30 06:00 [entrez]
PHST- 2013/10/30 06:00 [pubmed]
PHST- 2014/10/22 06:00 [medline]
AID - 17882773N528U451 [pii]
AID - 10.3233/JAD-131073 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2014;39(2):401-8. doi: 10.3233/JAD-131073.