PMID- 24165680
OWN - NLM
STAT- MEDLINE
DCOM- 20131227
LR  - 20220309
IS  - 1546-1726 (Electronic)
IS  - 1097-6256 (Linking)
VI  - 16
IP  - 11
DP  - 2013 Nov
TI  - mTOR complexes in neurodevelopmental and neuropsychiatric disorders.
PG  - 1537-43
LID - 10.1038/nn.3546 [doi]
AB  - The mechanistic target of rapamycin (mTOR) acts as a highly conserved signaling 
      "hub" that integrates neuronal activity and a variety of synaptic inputs. mTOR is 
      found in two functionally distinct complexes, mTORC1 and mTORC2, that crucially 
      control long-term synaptic efficacy and memory storage. Dysregulation of mTOR 
      signaling is associated with neurodevelopmental and neuropsychiatric disorders. 
      In this Review, we describe the most recent advances in studies of mTOR signaling 
      in the brain and the possible mechanisms underlying the many different functions 
      of the mTOR complexes in neurological diseases. In addition, we discuss the 
      medical relevance of these findings.
FAU - Costa-Mattioli, Mauro
AU  - Costa-Mattioli M
AD  - Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA.
FAU - Monteggia, Lisa M
AU  - Monteggia LM
LA  - eng
GR  - MH096816/MH/NIMH NIH HHS/United States
GR  - R01 NS076708/NS/NINDS NIH HHS/United States
GR  - NS076708/NS/NINDS NIH HHS/United States
GR  - R01 MH096816/MH/NIMH NIH HHS/United States
GR  - MH070727/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20131028
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Mental Disorders/complications/*metabolism
MH  - Nervous System Diseases/complications/*metabolism
MH  - Signal Transduction/genetics/*physiology
MH  - TOR Serine-Threonine Kinases/genetics/*metabolism
EDAT- 2013/10/30 06:00
MHDA- 2013/12/29 06:00
CRDT- 2013/10/30 06:00
PHST- 2013/06/10 00:00 [received]
PHST- 2013/09/11 00:00 [accepted]
PHST- 2013/10/30 06:00 [entrez]
PHST- 2013/10/30 06:00 [pubmed]
PHST- 2013/12/29 06:00 [medline]
AID - nn.3546 [pii]
AID - 10.1038/nn.3546 [doi]
PST - ppublish
SO  - Nat Neurosci. 2013 Nov;16(11):1537-43. doi: 10.1038/nn.3546. Epub 2013 Oct 28.