PMID- 24167351
OWN - NLM
STAT- MEDLINE
DCOM- 20140606
LR  - 20220331
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Print)
IS  - 0278-0240 (Linking)
VI  - 35
IP  - 2
DP  - 2013
TI  - HLA markers for poor prognosis in systemic sclerosis Brazilian patients.
PG  - 73-8
LID - 10.1155/2013/301415 [doi]
AB  - OBJECTIVES: The aim of this study was to evaluate human leukocyte antigen (HLA) 
      involvement in the disease expression and poor prognostic clinical features 
      (pulmonary fibrosis and pulmonary arterial hypertension) in patients diagnosed 
      with systemic sclerosis (SSc) in a multiethnic population. METHODS: SSc patients 
      followed up between 2008 and 2011 were included, and clinical data were obtained 
      through records review. Molecular HLA typing was performed (polymerase chain 
      reaction amplification technique using specific primer sequences). The 
      statistical analysis involved Fisher's exact test and Pearson's corrected 
      chi-square test. P (values) </= 0.05 were considered significant. The delta method 
      was used to estimate the variance of the prevalence ratio (PR). RESULTS: A total 
      of 141 patients (120 women and 21 men) with SSc were studied, including 33.3% 
      with diffuse cutaneous SSc (dcSSc), 62.4% with limited cutaneous SSc (lcSSc), and 
      4.3% with sine scleroderma. Pulmonary fibrosis was present in 61 patients 
      (43.3%), and the HLA-A *30 and DQB1 *04 alleles were related to susceptibility. In 
      contrast, the HLA-DRB1 *01 and DQB1 *05 alleles were protective. Pulmonary arterial 
      hypertension was diagnosed in 19 patients (13.5%) and was associated with 
      HLA-B *35 and C *04; in contrast, C *03 seemed to be protective. CONCLUSIONS: Our 
      current study documents the association of some classes I and II HLA alleles with 
      the most severe clinical manifestations in a multiethnic case series. Our 
      findings differed slightly from the previous data in other populations.
FAU - Del Rio, Ana Paula Toledo
AU  - Del Rio AP
AD  - Unit of Rheumatology, Department of Internal Medicine, Faculty of Medical 
      Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil.
FAU - Sachetto, Zoraida
AU  - Sachetto Z
FAU - Sampaio-Barros, Percival Degrava
AU  - Sampaio-Barros PD
FAU - Marques-Neto, Joao Francisco
AU  - Marques-Neto JF
FAU - Londe, Ana Carolina Santos
AU  - Londe AC
FAU - Bertolo, Manoel Barros
AU  - Bertolo MB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130728
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (Genetic Markers)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A*30 antigen)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*01 antigen)
SB  - IM
MH  - Brazil
MH  - Familial Primary Pulmonary Hypertension
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Markers
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-C Antigens/genetics
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Hypertension, Pulmonary/genetics
MH  - Male
MH  - Prognosis
MH  - Pulmonary Fibrosis/genetics
MH  - Scleroderma, Systemic/*genetics
PMC - PMC3774956
EDAT- 2013/10/30 06:00
MHDA- 2014/06/07 06:00
PMCR- 2013/07/28
CRDT- 2013/10/30 06:00
PHST- 2012/06/19 00:00 [received]
PHST- 2013/06/19 00:00 [revised]
PHST- 2013/07/04 00:00 [accepted]
PHST- 2013/10/30 06:00 [entrez]
PHST- 2013/10/30 06:00 [pubmed]
PHST- 2014/06/07 06:00 [medline]
PHST- 2013/07/28 00:00 [pmc-release]
AID - 10.1155/2013/301415 [doi]
PST - ppublish
SO  - Dis Markers. 2013;35(2):73-8. doi: 10.1155/2013/301415. Epub 2013 Jul 28.