PMID- 24168199
OWN - NLM
STAT- MEDLINE
DCOM- 20140709
LR  - 20240323
IS  - 1758-8936 (Electronic)
IS  - 1758-8928 (Print)
IS  - 1758-8928 (Linking)
VI  - 4
IP  - 3-4
DP  - 2013
TI  - The entorhinal cortex and neurotrophin signaling in Alzheimer's disease and other 
      disorders.
PG  - 123-35
LID - 10.1080/17588928.2013.826184 [doi]
AB  - A major problem in the field of neurodegeneration is the basis of selective 
      vulnerability of subsets of neurons to disease. In aging, Alzheimer's disease 
      (AD), and other disorders such as temporal lobe epilepsy, the superficial layers 
      of the entorhinal cortex (EC) are an area of selective vulnerability. In AD, it 
      has been suggested that the degeneration of these neurons may play a role in 
      causing the disease because it occurs at an early stage. Therefore, it is 
      important to define the distinctive characteristics of the EC that make this 
      region particularly vulnerable. It has been shown that neurotrophins such as 
      brain-derived neurotrophic factor (BDNF) are critical to the maintenance of the 
      cortical neurons in the adult brain, and specifically the EC. Here we review the 
      circuitry, distinctive functions, and neurotrophin-dependence of the EC that are 
      relevant to its vulnerability. We also suggest that a protein that is critical to 
      the actions of BDNF, the ARMS/Kidins220 scaffold protein, plays an important role 
      in neurotrophic support of the EC.
FAU - Scharfman, Helen E
AU  - Scharfman HE
AD  - a Departments of Child & Adolescent Psychiatry, Physiology & Neuroscience and 
      Psychiatry , New York University Langone Medical Center , New York , NY , USA.
FAU - Chao, Moses V
AU  - Chao MV
LA  - eng
GR  - R21 MH090606/MH/NIMH NIH HHS/United States
GR  - R21 MH084215/MH/NIMH NIH HHS/United States
GR  - R01 AG025970/AG/NIA NIH HHS/United States
GR  - R56 NS021072/NS/NINDS NIH HHS/United States
GR  - R01 NS021072/NS/NINDS NIH HHS/United States
GR  - P30 AG008051/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130825
PL  - England
TA  - Cogn Neurosci
JT  - Cognitive neuroscience
JID - 101518151
RN  - 0 (KIDINS220 protein, human)
RN  - 0 (Membrane Proteins)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
MH  - Adult
MH  - Alzheimer Disease/*physiopathology
MH  - Animals
MH  - Entorhinal Cortex/*physiology
MH  - Humans
MH  - Membrane Proteins/physiology
MH  - Nerve Growth Factors/*physiology
MH  - Nerve Tissue Proteins/physiology
MH  - Neurons/physiology
MH  - Primates
MH  - Rodentia
MH  - Signal Transduction/*physiology
PMC - PMC3836904
MID - NIHMS515203
COIS- The authors declare no conflicts of interest.
EDAT- 2013/10/31 06:00
MHDA- 2014/07/10 06:00
PMCR- 2014/09/01
CRDT- 2013/10/31 06:00
PHST- 2013/10/31 06:00 [entrez]
PHST- 2013/10/31 06:00 [pubmed]
PHST- 2014/07/10 06:00 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - 10.1080/17588928.2013.826184 [doi]
PST - ppublish
SO  - Cogn Neurosci. 2013;4(3-4):123-35. doi: 10.1080/17588928.2013.826184. Epub 2013 
      Aug 25.