PMID- 2416828
OWN - NLM
STAT- MEDLINE
DCOM- 19860218
LR  - 20071114
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 136
IP  - 3
DP  - 1986 Feb 1
TI  - Studies on immunity in hybridoma-bearing mice. B. Immunity against the hybridoma. 
      II. The phenotype and specificity of the immune cell.
PG  - 1131-5
AB  - When appropriate numbers of anti-dinitrophenyl (DNP) immunoglobulin (Ig) 
      E-secreting hybridoma (B 53) cells were injected s.c. into normal BALB/c mice, 
      some of the recipients rejected the tumors. These mice were shown to be immune to 
      B 53 as they withstood, without any ill effect, the i.p. injection of lethal 
      doses of B 53 cells. In previous studies, it was shown that the spleen cells of 
      these mice protected against the growth of B 53 cells. In this study, the 
      characteristics and specificity of the immune spleen cells were examined. The 
      cells responsible for this immunity were shown to be T cells that express Ly-2 on 
      their surface. These cells were shown in in vivo and in vitro assays to limit the 
      growth of the immunizing hybridoma, as well as some but not all BALB/c 
      plasmacytomas and hybridomas.
FAU - Maekawa, S
AU  - Maekawa S
FAU - Ovary, Z
AU  - Ovary Z
LA  - eng
GR  - AI-03075/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Chromium Radioisotopes)
RN  - 0 (Epitopes)
SB  - IM
MH  - Animals
MH  - Antigens, Neoplasm/*immunology
MH  - Chromium Radioisotopes/metabolism
MH  - Epitopes/*analysis
MH  - Female
MH  - Hybridomas/classification/*immunology
MH  - Immunity, Cellular
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Phenotype
MH  - Plasmacytoma/immunology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Spleen
MH  - T-Lymphocytes/*classification/immunology
EDAT- 1986/02/01 00:00
MHDA- 1986/02/01 00:01
CRDT- 1986/02/01 00:00
PHST- 1986/02/01 00:00 [pubmed]
PHST- 1986/02/01 00:01 [medline]
PHST- 1986/02/01 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1986 Feb 1;136(3):1131-5.