PMID- 24168815
OWN - NLM
STAT- MEDLINE
DCOM- 20140909
LR  - 20131122
IS  - 1879-2472 (Electronic)
IS  - 0049-3848 (Linking)
VI  - 132
IP  - 6
DP  - 2013
TI  - Evaluation of the prevalence of severe hyperhomocysteinemia in adult patients 
      with thrombosis who underwent screening for thrombophilia.
PG  - 681-4
LID - S0049-3848(13)00458-1 [pii]
LID - 10.1016/j.thromres.2013.09.038 [doi]
AB  - INTRODUCTION: Treatment with B-vitamins and betaine reduces the high risk of 
      thrombosis in patients with homocystinuria, a metabolic syndrome that is 
      characterized by severe hyperhomocysteinemia (HHcy). In contrast, there is no 
      clear demonstration that B-vitamins reduce the risk of thrombosis in patients 
      with mild HHcy: for this reason, many question the clinical utility of measuring 
      total Hcy (tHcy) in patients with thrombosis. However, thrombosis may be the 
      first clinical manifestation of homocystinuria in patients reaching adulthood 
      without signs and symptoms of the syndrome. AIM: 1) to measure the prevalence of 
      severe, previously undiagnosed, HHcy among patients with thrombosis 2) to profile 
      these patients on the basis of their characteristics. METHODS: Six Italian 
      Thrombosis Centers completed a first questionnaire, reporting tHcy levels in 
      patients with thrombosis who underwent thrombophilia screening, and a second 
      questionnaire, reporting the characteristics of patients with severe HHcy 
      (tHcy>100mumol/L). RESULTS: Of 19,678 cross-sectionally collected patients with 
      thrombosis who underwent thrombophilia screening in the last 12.5years (median 
      value, range 6-17), 38 had severe HHcy (0.2%). Their median age at diagnosis was 
      47years (range 19-83) and the median level of tHcy was 130mumol/L (range 101-262). 
      Venous thromboembolism (71%) was more frequent than arterial thromboembolism 
      (26%); recurrent thrombosis occurred in 42% of cases. CONCLUSIONS: Measurement of 
      tHcy in adult patients with thrombosis may reveal the presence of severe HHcy. 
      Since treatment of patients with severe HHcy decreases the risk of thrombosis, 
      measurement of tHcy in patients with thrombosis may prove clinically useful.
CI  - (c) 2013.
FAU - Lussana, Federico
AU  - Lussana F
AD  - Medicina III, Azienda Ospedaliera San Paolo, Dipartimento di Scienze della 
      Salute, Universita degli Studi di Milano, Milano, Italy. Electronic address: 
      federico.lussana@ao-sanpaolo.it.
FAU - Betti, Silvia
AU  - Betti S
FAU - D'Angelo, Armando
AU  - D'Angelo A
FAU - De Stefano, Valerio
AU  - De Stefano V
FAU - Fedi, Sandra
AU  - Fedi S
FAU - Ferrazzi, Paola
AU  - Ferrazzi P
FAU - Legnani, Cristina
AU  - Legnani C
FAU - Marcucci, Rossella
AU  - Marcucci R
FAU - Palareti, Gualtiero
AU  - Palareti G
FAU - Rota, Lidia L
AU  - Rota LL
FAU - Sampietro, Francesca
AU  - Sampietro F
FAU - Squizzato, Alessandro
AU  - Squizzato A
FAU - Prisco, Domenico
AU  - Prisco D
FAU - Cattaneo, Marco
AU  - Cattaneo M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131016
PL  - United States
TA  - Thromb Res
JT  - Thrombosis research
JID - 0326377
RN  - Homocysteinemia
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - Female
MH  - Homocystinuria/blood/*epidemiology
MH  - Humans
MH  - Hyperhomocysteinemia/blood/*epidemiology
MH  - Italy/epidemiology
MH  - Male
MH  - Mass Screening
MH  - Middle Aged
MH  - Prevalence
MH  - Thrombophilia/blood/diagnosis/*epidemiology
MH  - Thrombosis/blood/*epidemiology
MH  - Young Adult
OTO - NOTNLM
OT  - CBS
OT  - CI
OT  - Confidence Intervals
OT  - HHCy
OT  - Hcy
OT  - Homocysteine
OT  - Homocystinuria
OT  - Hyperhomocysteinemia
OT  - MTHFR
OT  - Thrombophilia
OT  - Thrombosis
OT  - cystathionine beta-synthase
OT  - homocysteine
OT  - hyperhomocysteine
OT  - methylene tethrahydrofolate reductase
OT  - tHcy
OT  - total homocysteine
EDAT- 2013/10/31 06:00
MHDA- 2014/09/10 06:00
CRDT- 2013/10/31 06:00
PHST- 2013/07/10 00:00 [received]
PHST- 2013/09/26 00:00 [revised]
PHST- 2013/09/30 00:00 [accepted]
PHST- 2013/10/31 06:00 [entrez]
PHST- 2013/10/31 06:00 [pubmed]
PHST- 2014/09/10 06:00 [medline]
AID - S0049-3848(13)00458-1 [pii]
AID - 10.1016/j.thromres.2013.09.038 [doi]
PST - ppublish
SO  - Thromb Res. 2013;132(6):681-4. doi: 10.1016/j.thromres.2013.09.038. Epub 2013 Oct 
      16.