PMID- 24168843
OWN - NLM
STAT- MEDLINE
DCOM- 20150622
LR  - 20181202
IS  - 1872-8952 (Electronic)
IS  - 1388-2457 (Linking)
VI  - 125
IP  - 4
DP  - 2014 Apr
TI  - Length dependent loss of motor axons and altered motor unit properties in human 
      diabetic polyneuropathy.
PG  - 836-843
LID - S1388-2457(13)01102-4 [pii]
LID - 10.1016/j.clinph.2013.09.037 [doi]
AB  - OBJECTIVE: To assess the number and properties of motor units in an upper and 
      lower limb muscle (tibialis anterior [TA] and first dorsal interosseous [FDI]) in 
      human diabetic polyneuropathy (DPN) using decomposition-based quantitative 
      electromyography (DQEMG). METHODS: DQEMG protocols were performed in the TA and 
      FDI of 12 patients with confirmed diabetes mellitus and associated DPN, as well 
      as 12 age-matched control participants. Maximal dorsiflexion strength was also 
      assessed using a dynamometer. RESULTS: In both muscles, patients with DPN had 
      significantly reduced motor unit number estimates (MUNEs) (DeltaTA  approximately 45%; DeltaFDI  approximately 30%), 
      compound muscle action potentials (CMAPs) (DeltaTA  approximately 30%; DeltaFDI  approximately 20%), and mean firing 
      rates were reduced (DeltaTA  approximately 15%; DeltaFDI  approximately 15%) compared to controls (p<0.05). For the 
      TA, patients with DPN had larger mean surface motor unit potentials (SMUPs) (DeltaTA 
       approximately 40%; p<0.05), whereas in the FDI no differences were found (p>0.05). 
      CONCLUSIONS: DPN may result in motor unit loss, remodeling, and altered firing 
      rate patterns. The magnitude of changes in the neuromuscular properties of DPN 
      patients are muscle dependent and reflect a length-dependent disease progression. 
      SIGNIFICANCE: DQEMG may be a clinically useful technique in identifying the 
      presence and severity of neuromuscular pathophysiology and tracking disease 
      progression in DPN.
CI  - Copyright (c) 2013 International Federation of Clinical Neurophysiology. Published 
      by Elsevier Ireland Ltd. All rights reserved.
FAU - Allen, Matti D
AU  - Allen MD
AD  - School of Kinesiology, Faculty of Health Sciences, The University of Western 
      Ontario, London, ON, Canada. Electronic address: mallen9@uwo.ca.
FAU - Kimpinski, Kurt
AU  - Kimpinski K
AD  - Department of Clinical Neurological Sciences, Schulich School of Medicine and 
      Dentistry, The University of Western Ontario, London, ON, Canada.
FAU - Doherty, Timothy J
AU  - Doherty TJ
AD  - School of Kinesiology, Faculty of Health Sciences, The University of Western 
      Ontario, London, ON, Canada; Department of Clinical Neurological Sciences, 
      Schulich School of Medicine and Dentistry, The University of Western Ontario, 
      London, ON, Canada; Department of Physical Medicine and Rehabilitation, Schulich 
      School of Medicine and Dentistry, The University of Western Ontario, London, ON, 
      Canada.
FAU - Rice, Charles L
AU  - Rice CL
AD  - School of Kinesiology, Faculty of Health Sciences, The University of Western 
      Ontario, London, ON, Canada; Department of Anatomy and Cell Biology, Schulich 
      School of Medicine and Dentistry, The University of Western Ontario, London, ON, 
      Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131026
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Adult
MH  - Aged
MH  - Axons/*pathology/physiology
MH  - Diabetic Neuropathies/*pathology/physiopathology
MH  - Disease Progression
MH  - Electromyography/methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Neurons/*pathology/physiology
MH  - Muscle, Skeletal/*pathology/physiology
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Diabetic neuropathy
OT  - Motor neuron
OT  - Motor unit
OT  - Weakness
EDAT- 2013/10/31 06:00
MHDA- 2015/06/24 06:00
CRDT- 2013/10/31 06:00
PHST- 2013/07/03 00:00 [received]
PHST- 2013/08/26 00:00 [revised]
PHST- 2013/09/30 00:00 [accepted]
PHST- 2013/10/31 06:00 [entrez]
PHST- 2013/10/31 06:00 [pubmed]
PHST- 2015/06/24 06:00 [medline]
AID - S1388-2457(13)01102-4 [pii]
AID - 10.1016/j.clinph.2013.09.037 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2014 Apr;125(4):836-843. doi: 10.1016/j.clinph.2013.09.037. 
      Epub 2013 Oct 26.