PMID- 24168964
OWN - NLM
STAT- MEDLINE
DCOM- 20140617
LR  - 20131206
IS  - 1879-0372 (Electronic)
IS  - 0952-7915 (Linking)
VI  - 25
IP  - 6
DP  - 2013 Dec
TI  - Dendritic cells in tolerance and autoimmune diabetes.
PG  - 670-5
LID - S0952-7915(13)00181-7 [pii]
LID - 10.1016/j.coi.2013.10.004 [doi]
AB  - Type 1 diabetes is a T cell mediated autoimmune disease where both central and 
      peripheral mechanisms effect T cell tolerance induction. Dendritic cells (DCs) 
      are key regulators of innate and adaptive immune responses. They significantly 
      contribute to central and peripheral T cell tolerance and, following maturation, 
      induce the activation and differentiation of naive T cells into effector and 
      memory cells. DCs are also major actors in inflammation. Given these multiple 
      effects on immune responses, DCs are suspected to contribute to autoimmune 
      diseases. In this review we discuss how some specific features of DC may 
      contribute to type 1 diabetes.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Guerder, Sylvie
AU  - Guerder S
AD  - Centre de Physiopathologie de Toulouse Purpan, Universite Toulouse III 
      Paul-Sabatier, Toulouse F-31300, France; INSERM, U1043, Toulouse F-31300, France; 
      CNRS, UMR5282, Toulouse F-31300, France. Electronic address: 
      sylvie.guerder@inserm.fr.
FAU - Joncker, Nathalie
AU  - Joncker N
FAU - Mahiddine, Karim
AU  - Mahiddine K
FAU - Serre, Laurent
AU  - Serre L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20131026
PL  - England
TA  - Curr Opin Immunol
JT  - Current opinion in immunology
JID - 8900118
RN  - EC 3.4.- (Serine Proteases)
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Dendritic Cells/*immunology
MH  - Diabetes Mellitus, Type 1/*immunology
MH  - Humans
MH  - *Immune Tolerance
MH  - Serine Proteases/immunology
MH  - Thymus Gland/immunology
EDAT- 2013/10/31 06:00
MHDA- 2014/06/18 06:00
CRDT- 2013/10/31 06:00
PHST- 2013/08/08 00:00 [received]
PHST- 2013/09/27 00:00 [revised]
PHST- 2013/10/03 00:00 [accepted]
PHST- 2013/10/31 06:00 [entrez]
PHST- 2013/10/31 06:00 [pubmed]
PHST- 2014/06/18 06:00 [medline]
AID - S0952-7915(13)00181-7 [pii]
AID - 10.1016/j.coi.2013.10.004 [doi]
PST - ppublish
SO  - Curr Opin Immunol. 2013 Dec;25(6):670-5. doi: 10.1016/j.coi.2013.10.004. Epub 
      2013 Oct 26.