PMID- 24171385
OWN - NLM
STAT- MEDLINE
DCOM- 20140623
LR  - 20240109
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 61
IP  - 46
DP  - 2013 Nov 20
TI  - Metabolomics of ginger essential oil against alcoholic fatty liver in mice.
PG  - 11231-40
LID - 10.1021/jf403523g [doi]
AB  - Fatty liver is significantly associated with hepatic cirrhosis and liver cancer. 
      Excessive alcohol consumption causes alcoholic fatty liver disease (AFLD). Ginger 
      has been reported to exhibit antioxidant potential and hepatoprotective activity. 
      In the present study, a mouse model for AFLD was developed by employing male 
      C57BL/6 mice that were fed an alcohol-containing liquid diet (Lieber-DeCarli 
      diet) ad libitum. In the treatment groups, ginger essential oil (GEO) and citral 
      were orally administered every day for 4 weeks. Serum biochemical analysis, 
      antioxidant enzyme activity analysis, and histopathological evaluation revealed 
      that GEO and citral exhibited hepatoprotective activity against AFLD. Metabolites 
      in serum samples were profiled by high-performance liquid chromatography coupled 
      with quadrupole time-of-flight mass spectrometry (HPLC-QTOF-MS). Metabolomic data 
      indicated the amounts of metabolites such as d-glucurono-6,3-lactone, 
      glycerol-3-phosphate, pyruvic acid, lithocholic acid, 2-pyrocatechuic acid, and 
      prostaglandin E1 were increased after alcohol administration, but the levels were 
      recovered in treatment groups. The analysis indicated that ginger possesses 
      hepatoprotective properties against AFLD. Furthermore, these metabolites can 
      serve as early noninvasive candidate biomarkers in the clinical application of 
      AFLD for health management.
FAU - Liu, Chun-Ting
AU  - Liu CT
AD  - Institute of Food Science and Technology, College of Bio-Resources and 
      Agriculture, National Taiwan University , Taipei 106, Taiwan.
FAU - Raghu, Rajasekaran
AU  - Raghu R
FAU - Lin, Shu-Hsi
AU  - Lin SH
FAU - Wang, San-Yuan
AU  - Wang SY
FAU - Kuo, Ching-Hua
AU  - Kuo CH
FAU - Tseng, Yufeng J
AU  - Tseng YJ
FAU - Sheen, Lee-Yan
AU  - Sheen LY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131112
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Hydroxybenzoates)
RN  - 0 (Oils, Volatile)
RN  - 0 (Plant Oils)
RN  - 70D5FBB392 (2,3-dihydroxybenzoic acid)
RN  - 8558G7RUTR (Pyruvic Acid)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Fatty Liver, Alcoholic/*drug therapy/metabolism
MH  - Zingiber officinale/*chemistry
MH  - Humans
MH  - Hydroxybenzoates/metabolism
MH  - Liver/drug effects/metabolism
MH  - Male
MH  - Metabolomics
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Oils, Volatile/*administration & dosage/chemistry
MH  - Plant Oils/*administration & dosage
MH  - Pyruvic Acid/metabolism
EDAT- 2013/11/01 06:00
MHDA- 2014/06/24 06:00
CRDT- 2013/11/01 06:00
PHST- 2013/11/01 06:00 [entrez]
PHST- 2013/11/01 06:00 [pubmed]
PHST- 2014/06/24 06:00 [medline]
AID - 10.1021/jf403523g [doi]
PST - ppublish
SO  - J Agric Food Chem. 2013 Nov 20;61(46):11231-40. doi: 10.1021/jf403523g. Epub 2013 
      Nov 12.