PMID- 24171782
OWN - NLM
STAT- MEDLINE
DCOM- 20140902
LR  - 20240506
IS  - 1745-6215 (Electronic)
IS  - 1745-6215 (Linking)
VI  - 14
DP  - 2013 Oct 30
TI  - Evaluating the prophylaxis and long-term effectiveness of acupuncture for 
      migraine without aura: study protocol for a randomized controlled trial.
PG  - 361
LID - 10.1186/1745-6215-14-361 [doi]
AB  - BACKGROUND: The instant-treatment effect of acupuncture for patients with 
      migraines has been corroborated in numerous studies. However, most diseases are 
      chronic and tend to recur, so the long-term effect of acupuncture can verify the 
      existence of sustained efficacy or the placebo effect. Evaluating the efficacy of 
      acupuncture in the prophylaxis of migraine without aura (MWoA) in China is also 
      important because such studies are lacking. METHODS: This trial is a multicenter, 
      prospective, pragmatic randomized controlled clinical trial. We will randomly 
      allocate 249 participants to three groups of 83. Patients in the individualized 
      acupoint group will be treated with individualized acupuncture point 
      prescriptions. The non-acupoint control group will undergo insertion of 
      acupuncture needles at four bilateral non-points in locations not corresponding 
      to acupuncture points. The waiting-list control group will not undergo treatment 
      but instead will receive 20 acupuncture treatments for free after a waiting 
      period of 24 weeks. Participants in the individualized acupoint group and 
      non-acupoint control group will receive 20 sessions over four weeks and then all 
      participants will receive 20 weeks of follow-up. DISCUSSION: The results of our 
      trial will help to supply evidence for the long-term acupuncture effect for MWoA 
      in a long follow-up period, and special attention will be paid to comparison with 
      the placebo effect. TRIAL REGISTRATION: The trial was registered at 
      ClinicalTrials.gov (NCT01687660) on 18 September 2012.
FAU - Chen, Jiao
AU  - Chen J
FAU - Zhao, Ling
AU  - Zhao L
FAU - Zheng, Hui
AU  - Zheng H
FAU - Li, Ying
AU  - Li Y
FAU - Yang, Mingxiao
AU  - Yang M
FAU - Chang, Xiaorong
AU  - Chang X
FAU - Gong, Biao
AU  - Gong B
FAU - Huang, Yinlan
AU  - Huang Y
FAU - Liu, Yanqin
AU  - Liu Y
FAU - Liang, Fanrong
AU  - Liang F
AD  - Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. 
      acuresearch@126.com.
LA  - eng
SI  - ClinicalTrials.gov/NCT01687660
PT  - Journal Article
PT  - Multicenter Study
PT  - Pragmatic Clinical Trial
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20131030
PL  - England
TA  - Trials
JT  - Trials
JID - 101263253
SB  - IM
MH  - *Acupuncture Therapy
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - China
MH  - Clinical Protocols
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Migraine without Aura/diagnosis/*therapy
MH  - Pain Measurement
MH  - Prospective Studies
MH  - *Research Design
MH  - Secondary Prevention
MH  - Time Factors
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC3816544
EDAT- 2013/11/01 06:00
MHDA- 2014/09/03 06:00
PMCR- 2013/10/30
CRDT- 2013/11/01 06:00
PHST- 2013/04/14 00:00 [received]
PHST- 2013/10/21 00:00 [accepted]
PHST- 2013/11/01 06:00 [entrez]
PHST- 2013/11/01 06:00 [pubmed]
PHST- 2014/09/03 06:00 [medline]
PHST- 2013/10/30 00:00 [pmc-release]
AID - 1745-6215-14-361 [pii]
AID - 10.1186/1745-6215-14-361 [doi]
PST - epublish
SO  - Trials. 2013 Oct 30;14:361. doi: 10.1186/1745-6215-14-361.