PMID- 24172034
OWN - NLM
STAT- MEDLINE
DCOM- 20140910
LR  - 20131224
IS  - 1878-3252 (Electronic)
IS  - 0946-672X (Linking)
VI  - 28
IP  - 1
DP  - 2014 Jan
TI  - Protective effect of omega-3 fatty acid against mercury chloride intoxication in 
      mice.
PG  - 94-9
LID - S0946-672X(13)00103-X [pii]
LID - 10.1016/j.jtemb.2013.08.004 [doi]
AB  - The aim of this study was to investigate the protective effect of omega-3 fatty 
      acid in HgCI2 toxicity in mice. Levels of malondialdehyde (MDA), reduced 
      glutathione (GSH), nitric oxide (NO) and total sialic acid (TSA), and 
      histopathological changes in selected organs were evaluated. Twenty-eight mice 
      were equally divided into 4 groups, namely Groups I-IV. Group I animals received 
      intraperitoneal (ip) injection of physiological saline solution; Group II animals 
      received ip injection of 0.4mg/kg/day HgCI2; Group III animals received ip 
      injection of 0.4mg/kg/day HgCI2 in addition to subcutaneous (sc) injection of 
      0.5g/kg/day omega-3 fatty acid; and Group IV animals received sc injection of 
      0.5g/kg/day omega-3 fatty acid. All treatments lasted 7 days. The levels of MDA, 
      NO and TSA were significantly higher in Group II and lower in Groups III and IV 
      as compared to the Group I. GSH level was the highest in Group IV. In 
      histopathology, severe degeneration in liver and kidney was observed in Group II 
      animals. These degrading changes were seen to be reduced greatly in Group III 
      animals. The results suggested that omega-3 fatty acid might attenuate 
      HgCI2-induced toxicity by improving antioxidant status and acute phase response 
      in mice.
CI  - Copyright (c) 2013 Elsevier GmbH. All rights reserved.
FAU - Karapehlivan, Mahmut
AU  - Karapehlivan M
AD  - Department of Biochemistry, Faculty of Veterinary Medicine, Kafkas University, 
      36100 Kars, Turkey.
FAU - Ogun, Metin
AU  - Ogun M
AD  - Department of Biochemistry, Faculty of Veterinary Medicine, Kafkas University, 
      36100 Kars, Turkey.
FAU - Kaya, Inan
AU  - Kaya I
AD  - Department of Molecular Biology and Genetic, Faculty of Arts and Science, Kafkas 
      University, 36100 Kars, Turkey. Electronic address: inankaya_@hotmail.com.
FAU - Ozen, Hasan
AU  - Ozen H
AD  - Department of Pathology, Faculty of Veterinary Medicine, Kafkas University, 36100 
      Kars, Turkey.
FAU - Deveci, Haci Ahmet
AU  - Deveci HA
AD  - Ataturk Health Services Vocational School, Kafkas University, 36100 Kars, Turkey.
FAU - Karaman, Musa
AU  - Karaman M
AD  - Department of Pathology, Faculty of Veterinary Medicine, Kafkas University, 36100 
      Kars, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20130908
PL  - Germany
TA  - J Trace Elem Med Biol
JT  - Journal of trace elements in medicine and biology : organ of the Society for 
      Minerals and Trace Elements (GMS)
JID - 9508274
RN  - 0 (Antioxidants)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 53GH7MZT1R (Mercuric Chloride)
RN  - GAN16C9B8O (Glutathione)
RN  - GZP2782OP0 (N-Acetylneuraminic Acid)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Fatty Acids, Omega-3/*pharmacology
MH  - Glutathione/metabolism
MH  - Lipid Peroxidation/drug effects
MH  - Malondialdehyde/metabolism
MH  - Mercuric Chloride/*toxicity
MH  - Mice
MH  - N-Acetylneuraminic Acid/metabolism
MH  - Nitric Oxide/metabolism
OTO - NOTNLM
OT  - Malondialdehyde
OT  - Mercury chloride
OT  - Nitric oxide
OT  - Omega-3 fatty acid
OT  - Sialic acid
EDAT- 2013/11/01 06:00
MHDA- 2014/09/11 06:00
CRDT- 2013/11/01 06:00
PHST- 2013/06/04 00:00 [received]
PHST- 2013/08/03 00:00 [revised]
PHST- 2013/08/30 00:00 [accepted]
PHST- 2013/11/01 06:00 [entrez]
PHST- 2013/11/01 06:00 [pubmed]
PHST- 2014/09/11 06:00 [medline]
AID - S0946-672X(13)00103-X [pii]
AID - 10.1016/j.jtemb.2013.08.004 [doi]
PST - ppublish
SO  - J Trace Elem Med Biol. 2014 Jan;28(1):94-9. doi: 10.1016/j.jtemb.2013.08.004. 
      Epub 2013 Sep 8.