PMID- 24173712
OWN - NLM
STAT- MEDLINE
DCOM- 20150708
LR  - 20211021
IS  - 1615-2573 (Electronic)
IS  - 0910-8327 (Linking)
VI  - 29
IP  - 6
DP  - 2014 Nov
TI  - Increased soluble vascular adhesion molecule-1 concentration is associated with 
      impaired coronary flow reserve in cardiac syndrome X.
PG  - 723-31
LID - 10.1007/s00380-013-0414-2 [doi]
AB  - It is well known that both atherosclerosis initiated by endothelial dysfunction 
      due to inflammatory cascade and coronary flow reserve (CFR) are useful in the 
      functional or risk assessment of coronary microcirculation. The aim of this study 
      is to elucidate the association between early atherosclerotic inflammatory 
      markers and CFR using transthoracic echocardiography (TTE) in subjects with 
      cardiac syndrome X. A total of 135 individuals (mean age 56 +/- 9 years, 79 males 
      and 56 females) with angina or angina-like chest pain and a normal coronary 
      angiogram were enrolled. The early inflammatory biomarkers related to 
      atherosclerosis, namely soluble vascular adhesion molecule-1 (sVCAM-1), 
      interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and 
      lipoprotein-associated phospholipase A2 (Lp-PLA2), were compared with analyzed 
      CFR, using TTE and adenosine or dipyridamole, measured within 2 weeks after 
      coronary angiography. There was an inverse correlation between sVCAM-1 and CFR (r 
      = -0.225, P = 0.014). In the two groups divided by a CFR of 2.0, sVCAM-1 was 
      significantly higher in the group with CFR <2.0 than in the group with CFR >/=2.0 
      (n = 21: 757 +/- 323 ng/ml, vs n = 114: 628 +/- 146 ng/ml, P = 0.007). In 
      multivariate analysis, sVCAM-1 was an independent factor related to a CFR <2.0 
      (odds ratio 1.003, 95 % confidence interval 1.001-1.006, P = 0.023). Our results 
      showed that sVCAM-1 levels were inversely associated with CFR using TTE in 
      cardiac syndrome X. Further studies are warranted to validate whether increased 
      sVCAM-1 concentration, as an inflammatory modulator, is reflected in the presence 
      of subclinical coronary atherosclerosis.
FAU - Shim, Byung Ju
AU  - Shim BJ
AD  - Division of Cardiology, Department of Internal Medicine, College of Medicine, The 
      Catholic University of Korea, Seoul, Korea.
FAU - Lee, Dong Hyeon
AU  - Lee DH
FAU - Youn, Ho Joong
AU  - Youn HJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131031
PL  - Japan
TA  - Heart Vessels
JT  - Heart and vessels
JID - 8511258
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - EC 3.1.1.47 (1-Alkyl-2-acetylglycerophosphocholine Esterase)
SB  - IM
MH  - 1-Alkyl-2-acetylglycerophosphocholine Esterase/metabolism
MH  - Biomarkers/metabolism
MH  - Chemokine CCL2/metabolism
MH  - Coronary Angiography/methods
MH  - Coronary Artery Disease/*metabolism
MH  - Echocardiography
MH  - Endothelium, Vascular/*metabolism
MH  - Female
MH  - Fractional Flow Reserve, Myocardial/*physiology
MH  - Humans
MH  - Interleukin-6/metabolism
MH  - Male
MH  - Microcirculation
MH  - *Microvascular Angina/blood/physiopathology
MH  - Middle Aged
MH  - Vascular Cell Adhesion Molecule-1/*blood
EDAT- 2013/11/01 06:00
MHDA- 2015/07/15 06:00
CRDT- 2013/11/01 06:00
PHST- 2013/02/06 00:00 [received]
PHST- 2013/09/13 00:00 [accepted]
PHST- 2013/11/01 06:00 [entrez]
PHST- 2013/11/01 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - 10.1007/s00380-013-0414-2 [doi]
PST - ppublish
SO  - Heart Vessels. 2014 Nov;29(6):723-31. doi: 10.1007/s00380-013-0414-2. Epub 2013 
      Oct 31.