PMID- 24174648
OWN - NLM
STAT- MEDLINE
DCOM- 20140826
LR  - 20211021
IS  - 1522-1598 (Electronic)
IS  - 0022-3077 (Print)
IS  - 0022-3077 (Linking)
VI  - 111
IP  - 2
DP  - 2014 Jan
TI  - Activity of long-lead burst neurons in pontine reticular formation during 
      head-unrestrained gaze shifts.
PG  - 300-12
LID - 10.1152/jn.00841.2012 [doi]
AB  - Primates explore a visual scene through a succession of saccades. Much of what is 
      known about the neural circuitry that generates these movements has come from 
      neurophysiological studies using subjects with their heads restrained. Horizontal 
      saccades and the horizontal components of oblique saccades are associated with 
      high-frequency bursts of spikes in medium-lead burst neurons (MLBs) and long-lead 
      burst neurons (LLBNs) in the paramedian pontine reticular formation. For LLBNs, 
      the high-frequency burst is preceded by a low-frequency prelude that begins 
      12-150 ms before saccade onset. In terms of the lead time between the onset of 
      prelude activity and saccade onset, the anatomical projections, and the movement 
      field characteristics, LLBNs are a heterogeneous group of neurons. Whether this 
      heterogeneity is endemic of multiple functional subclasses is an open question. 
      One possibility is that some may carry signals related to head movement. We 
      recorded from LLBNs while monkeys performed head-unrestrained gaze shifts, during 
      which the kinematics of the eye and head components were dissociable. Many cells 
      had peak firing rates that never exceeded 200 spikes/s for gaze shifts of any 
      vector. The activity of these low-frequency cells often persisted beyond the end 
      of the gaze shift and was usually related to head-movement kinematics. A subset 
      was tested during head-unrestrained pursuit and showed clear modulation in the 
      absence of saccades. These "low-frequency" cells were intermingled with MLBs and 
      traditional LLBNs and may represent a separate functional class carrying signals 
      related to head movement.
FAU - Walton, Mark M G
AU  - Walton MM
AD  - Department of Neurobiology and Anatomy, University of Rochester, Rochester, New 
      York; and.
FAU - Freedman, Edward G
AU  - Freedman EG
LA  - eng
GR  - EY-13239/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20131030
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
SB  - IM
MH  - *Action Potentials
MH  - Animals
MH  - *Head Movements
MH  - Macaca mulatta
MH  - Neurons/classification/*physiology
MH  - Pons/cytology/*physiology
MH  - Reticular Formation/cytology/*physiology
MH  - *Saccades
PMC - PMC3921377
OTO - NOTNLM
OT  - PPRF
OT  - gaze
OT  - head movement
OT  - primate
OT  - saccade
EDAT- 2013/11/01 06:00
MHDA- 2014/08/27 06:00
PMCR- 2015/01/15
CRDT- 2013/11/01 06:00
PHST- 2013/11/01 06:00 [entrez]
PHST- 2013/11/01 06:00 [pubmed]
PHST- 2014/08/27 06:00 [medline]
PHST- 2015/01/15 00:00 [pmc-release]
AID - jn.00841.2012 [pii]
AID - JN-00841-2012 [pii]
AID - 10.1152/jn.00841.2012 [doi]
PST - ppublish
SO  - J Neurophysiol. 2014 Jan;111(2):300-12. doi: 10.1152/jn.00841.2012. Epub 2013 Oct 
      30.