PMID- 24174684
OWN - NLM
STAT- MEDLINE
DCOM- 20131223
LR  - 20211021
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 33
IP  - 44
DP  - 2013 Oct 30
TI  - Functional connectivity in healthy subjects is nonlinearly modulated by the COMT 
      and DRD2 polymorphisms in a functional system-dependent manner.
PG  - 17519-26
LID - 10.1523/JNEUROSCI.2163-13.2013 [doi]
AB  - The dopamine system is known to modulate brain function in an inverted U-shaped 
      manner. Recently, the functional networks of the brain were categorized into two 
      systems, a "control system" and a "processing system." However, it remains 
      unclear whether the inverted U-shaped model of dopaminergic modulation could be 
      applied to both of these functional systems. The catechol-O-methyltransferase 
      (COMT) and dopamine D2 receptor (DRD2) were genotyped in 258 healthy young human 
      subjects. The local and long-range functional connectivity densities (FCDs) of 
      each voxel were calculated and compared in a voxel-wise manner using a two-way 
      (COMT and DRD2 genotypes) analysis of covariance. The resting-state functional 
      connectivity analysis was performed to determine the functional networks to which 
      brain regions with significant FCD differences belonged. Significant COMT x DRD2 
      interaction effects were found in the local FCDs of the superior portion of the 
      right temporal pole (sTP) and left lingual gyrus (LG) and in the long-range FCDs 
      of the right putamen and left medial prefrontal cortex (MPFC). Post hoc tests 
      showed nonlinear relationships between the genotypic subgroups and FCD. In the 
      control system, the sTP and putamen, components of the salience network, showed a 
      U-shaped modulation by dopamine signaling. In the processing system, however, the 
      MPFC of the default-mode network and the LG of the visual network showed an 
      inverted U-shaped modulation by the dopamine system. Our findings suggest an 
      interaction between COMT and DRD2 genotypes and show a functional 
      system-dependent modulation of dopamine signaling.
FAU - Tian, Tian
AU  - Tian T
AD  - Department of Radiology, Tianjin Medical University General Hospital, Tianjin, 
      China, Brainnetome Center and National Laboratory of Pattern Recognition, 
      Institute of Automation, Chinese Academy of Sciences, Beijing, China, Key 
      Laboratory for NeuroInformation of Ministry of Education, School of Life Science 
      and Technology, University of Electronic Science and Technology of China, 
      Chengdu, China, and Queensland Brain Institute, University of Queensland, 
      Brisbane, Queensland 4072, Australia.
FAU - Qin, Wen
AU  - Qin W
FAU - Liu, Bing
AU  - Liu B
FAU - Jiang, Tianzi
AU  - Jiang T
FAU - Yu, Chunshui
AU  - Yu C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (DRD2 protein, human)
RN  - 0 (Receptors, Dopamine D2)
RN  - EC 2.1.1.6 (Catechol O-Methyltransferase)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Catechol O-Methyltransferase/*genetics
MH  - Cell Communication/genetics/physiology
MH  - Dopamine/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Nerve Net/cytology/*physiology
MH  - Neural Pathways/cytology/metabolism/physiology
MH  - *Nonlinear Dynamics
MH  - Polymorphism, Genetic/*physiology
MH  - Receptors, Dopamine D2/*genetics
MH  - Young Adult
PMC - PMC6618357
EDAT- 2013/11/01 06:00
MHDA- 2013/12/24 06:00
PMCR- 2014/04/30
CRDT- 2013/11/01 06:00
PHST- 2013/11/01 06:00 [entrez]
PHST- 2013/11/01 06:00 [pubmed]
PHST- 2013/12/24 06:00 [medline]
PHST- 2014/04/30 00:00 [pmc-release]
AID - 33/44/17519 [pii]
AID - 2163-13 [pii]
AID - 10.1523/JNEUROSCI.2163-13.2013 [doi]
PST - ppublish
SO  - J Neurosci. 2013 Oct 30;33(44):17519-26. doi: 10.1523/JNEUROSCI.2163-13.2013.