PMID- 24175104
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131031
LR  - 20211021
IS  - 2090-6463 (Print)
IS  - 2090-6471 (Electronic)
IS  - 2090-6463 (Linking)
VI  - 2013
DP  - 2013
TI  - Everolimus for compassionate use in multiple Basal cell carcinomas.
PG  - 604301
LID - 10.1155/2013/604301 [doi]
LID - 604301
AB  - Everolimus is an inhibitor of the mammalian target of rapamycin (mTOR) and has 
      been shown to have antineoplastic activity in addition to its use as an 
      immunosuppressive agent for the prevention of organ transplant rejection. We 
      report the use of everolimus for the compassionate treatment of four elderly, 
      nontransplant patients presenting with multiple basal cell carcinomas (BCC). All 
      patients had a long history of BCC, had refused surgery as a current treatment 
      option, and did not respond to alternative treatments (including topical 
      5-fluorouracil and imiquimod). Patients were treated with oral everolimus 
      (1.5-3.0 mg daily) for 12 months or longer: a complete and sustained response was 
      seen in one case, and partial responses were seen in two other cases. Everolimus 
      was well tolerated in these elderly patients. These promising preliminary data 
      suggest that further dose-finding, controlled clinical studies are warranted to 
      evaluate the antineoplastic effects of everolimus in patients affected by BCC who 
      cannot or will not undergo surgery.
FAU - Eibenschutz, Laura
AU  - Eibenschutz L
AD  - Dipartimento Clinico Sperimentale di Dermatologia Oncologica, Istituto Santa 
      Maria e San Gallicano IRCCS, Via Fermo Ognibene 23, 00144 Roma, Italy.
FAU - Colombo, Delia
AU  - Colombo D
FAU - Catricala, Caterina
AU  - Catricala C
LA  - eng
PT  - Journal Article
DEP - 20130923
PL  - United States
TA  - Case Rep Dermatol Med
JT  - Case reports in dermatological medicine
JID - 101591808
PMC - PMC3794648
EDAT- 2013/11/01 06:00
MHDA- 2013/11/01 06:01
PMCR- 2013/09/23
CRDT- 2013/11/01 06:00
PHST- 2013/07/25 00:00 [received]
PHST- 2013/08/14 00:00 [accepted]
PHST- 2013/11/01 06:00 [entrez]
PHST- 2013/11/01 06:00 [pubmed]
PHST- 2013/11/01 06:01 [medline]
PHST- 2013/09/23 00:00 [pmc-release]
AID - 10.1155/2013/604301 [doi]
PST - ppublish
SO  - Case Rep Dermatol Med. 2013;2013:604301. doi: 10.1155/2013/604301. Epub 2013 Sep 
      23.