PMID- 24175263
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131031
LR  - 20211021
IS  - 2220-6124 (Print)
IS  - 2220-6124 (Electronic)
IS  - 2220-6124 (Linking)
VI  - 2
IP  - 2
DP  - 2013 May 6
TI  - Inflammatory status in chronic renal failure: The role of homocysteinemia and 
      pro-inflammatory cytokines.
PG  - 31-7
LID - 10.5527/wjn.v2.i2.31 [doi]
AB  - AIM: To evaluate determinants of inflammatory markers in chronic renal failure 
      patients according to the level of glomerular filtration rate. METHODS: One 
      hundred fifty four patients (Age: 44 +/- 06 years; male/female: 66/88) with chronic 
      renal failure (CRF) were divided into 6 groups according to the National Kidney 
      Foundation (NKF) classification. They included 28 primary stage renal failure 
      patients (CRF 1), 28 moderate stage renal failure patients (CRF 2), 28 severe 
      stage renal failure patients (CRF 3), 18 end-stage renal failure patients (CRF 
      4), 40 hemodialysis (HD) patients, and 12 peritoneal dialysis (PD) patients. 
      Tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and 
      C-reactive protein (CRP) were analyzed by immunosorbent assay kit (ELISA) (Cayman 
      Chemical's ACETM EIA kit). Immunoassay methods were used for total homocysteine 
      (tHcy) (fluorescence polarization immunoanalysis HPLC, PerkinEmer 200 series), 
      transferrin (MININEPHTM human transferin kit: ZK070.R), ferritin (ADVIA Centaur) 
      and fibrinogen analysis (ACL 200). Differences between groups were performed 
      using SPSS 20.0 and data are expressed as the mean +/- SD. RESULTS: Results showed 
      that in comparison with CRF 1 group and other groups, TNF-alpha and IL-6 levels were 
      respectively more elevated in HD (16.38 +/- 5.52 pg/mL vs 0.39 +/- 0.03 pg/mL, 11.05 
      +/- 3.59 pg/mL vs 8.20 +/- 0.22 pg/mL, P < 0.001) and PD (14.04 +/- 3.40 pg/mL vs 0.39 
      +/- 0.03 pg/mL, 10.15 +/- 1.66 pg/mL vs 8.20 +/- 0.22 pg/mL, P < 0.001). IL-1beta levels 
      were increased in HD (9.63 +/- 3.50 pg/mL vs 3.24 +/- 0.10 pg/mL, P < 0.001) and CRF 
      4 (7.76 +/- 0.66 pg/mL vs 3.24 +/- 0.10 pg/mL, P < 0.001) patients than in CRF 1 and 
      in the other groups. Plasma tHcy levels were higher in HD (32.27 +/- 12.08 mumol/L) 
      and PD (28.37 +/- 4.98 mumol/L) patients compared to the other groups of CRF (P < 
      0.001). The serum CRP level was significantly increased in HD (18.17 +/- 6.38 mg/L) 
      and PD (17.97 +/- 4.85 mg/L) patients compared to the other groups of CRF patients 
      (P < 0.001). The plasma fibrinogen level was more elevated in HD (6.86 +/- 1.06 
      g/L) and CRF 4 (6.05 +/- 0.57 g/L) than in the other groups (P < 0.001). 
      Furthermore; the ferritin level was higher in HD (169.90 +/- 62.16 ng/mL) and PD 
      (90.08 +/- 22.09 ng/mL) patients compared to the other groups of CRF (P < 0.001). 
      The serum transferrin value was significantly decreased especially in PD (1.78 +/- 
      0.21 g/L) compared to the other groups (P < 0.001). We found a negative 
      correlation between glomerular filtration rate (GFR), TNF-alpha levels (r = -0.75, P 
      < 0.001), and tHcy levels (r = -0.68, P < 0.001). We observed a positive 
      correlation between GFR and transferrin levels (r = 0.60, P < 0.001). CONCLUSION: 
      CRF was associated with elevated inflammatory markers. The inflammation was 
      observed at the severe stage of CRF and increases with progression of renal 
      failure.
FAU - Tbahriti, Hadja Fatima
AU  - Tbahriti HF
AD  - Hadja Fatima Tbahriti, Malika Bouchenak, Khedidja Mekki, Laboratoire de Nutrition 
      Clinique et Metabolique, Faculte des Sciences de la Nature et de la Vie, 
      Universite d'Oran, Oran 31100, Algerie.
FAU - Meknassi, Djamel
AU  - Meknassi D
FAU - Moussaoui, Rachid
AU  - Moussaoui R
FAU - Messaoudi, Amar
AU  - Messaoudi A
FAU - Zemour, Lakhdar
AU  - Zemour L
FAU - Kaddous, Abbou
AU  - Kaddous A
FAU - Bouchenak, Malika
AU  - Bouchenak M
FAU - Mekki, Khedidja
AU  - Mekki K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Nephrol
JT  - World journal of nephrology
JID - 101610229
PMC - PMC3782222
OTO - NOTNLM
OT  - Chronic renal failure
OT  - Glomerular filtration rate
OT  - Inflammation
OT  - Pro-inflammatory cytokines
OT  - Total homocysteine
EDAT- 2013/11/01 06:00
MHDA- 2013/11/01 06:01
PMCR- 2013/05/06
CRDT- 2013/11/01 06:00
PHST- 2013/02/25 00:00 [received]
PHST- 2013/04/27 00:00 [revised]
PHST- 2013/05/01 00:00 [accepted]
PHST- 2013/11/01 06:00 [entrez]
PHST- 2013/11/01 06:00 [pubmed]
PHST- 2013/11/01 06:01 [medline]
PHST- 2013/05/06 00:00 [pmc-release]
AID - 10.5527/wjn.v2.i2.31 [doi]
PST - ppublish
SO  - World J Nephrol. 2013 May 6;2(2):31-7. doi: 10.5527/wjn.v2.i2.31.