PMID- 24175304
OWN - NLM
STAT- MEDLINE
DCOM- 20140623
LR  - 20211021
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2013
DP  - 2013
TI  - First evidence of increased plasma serotonin levels in Tako-Tsubo cardiomyopathy.
PG  - 847069
LID - 10.1155/2013/847069 [doi]
LID - 847069
AB  - BACKGROUND: There is no data about the serotonergic activity during the acute 
      phase of Tako-Tsubo Cardiomyopathy (TTC). The objective of our study was to 
      investigate evidence of serotonin release from patients with TTC in comparison 
      with patients with ST elevation myocardial infarction (STEMI) and healthy control 
      subjects (HCS). METHODS AND RESULTS: Plasma serotonin levels in 14 consecutive 
      patients with TTC were compared with those in 14 patients with STEMI and 14 HCS. 
      Plasma serotonin levels at admission were markedly higher in patients with TTC 
      and STEMI as compared to HCS (3.9 +/- 4.6, P = 0.02 versus control; 5.7 +/- 5.6, P = 
      0.001 versus control; and 1 +/- 0.4 ng/mL, resp.). There was no difference in 
      serotonin levels between patients with TTC and those with STEMI (P = 0.33). 
      CONCLUSION: This finding suggests that serotonin could participate to the 
      pathophysiology of TTC.
FAU - Rouzaud Laborde, C
AU  - Rouzaud Laborde C
AD  - Inserm, Metabolic and Cardiovascular Disease Institute of Rangueil, 31432 
      Toulouse, France ; Paul Sabatier University, 31062 Toulouse, France ; Department 
      of Pharmacy, University Hospital Center, 31059 Toulouse, France.
FAU - Delmas, C
AU  - Delmas C
FAU - Mialet-Perez, J
AU  - Mialet-Perez J
FAU - Pizzinat, N
AU  - Pizzinat N
FAU - Biendel-Picquet, C
AU  - Biendel-Picquet C
FAU - Boudou, N
AU  - Boudou N
FAU - Dumonteil, N
AU  - Dumonteil N
FAU - Spreux-Varoquaux, O
AU  - Spreux-Varoquaux O
FAU - Carrie, D
AU  - Carrie D
FAU - Galinier, M
AU  - Galinier M
FAU - Parini, A
AU  - Parini A
FAU - Lairez, O
AU  - Lairez O
LA  - eng
PT  - Journal Article
DEP - 20130923
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/blood
MH  - Myocardial Stunning/blood
MH  - Serotonin/*blood/physiology
MH  - Stress, Physiological
MH  - Stress, Psychological
MH  - Takotsubo Cardiomyopathy/*blood/etiology/physiopathology
PMC - PMC3794635
EDAT- 2013/11/01 06:00
MHDA- 2014/06/24 06:00
PMCR- 2013/09/23
CRDT- 2013/11/01 06:00
PHST- 2013/04/09 00:00 [received]
PHST- 2013/08/06 00:00 [revised]
PHST- 2013/08/12 00:00 [accepted]
PHST- 2013/11/01 06:00 [entrez]
PHST- 2013/11/01 06:00 [pubmed]
PHST- 2014/06/24 06:00 [medline]
PHST- 2013/09/23 00:00 [pmc-release]
AID - 10.1155/2013/847069 [doi]
PST - ppublish
SO  - Biomed Res Int. 2013;2013:847069. doi: 10.1155/2013/847069. Epub 2013 Sep 23.