PMID- 24176217
OWN - NLM
STAT- MEDLINE
DCOM- 20140609
LR  - 20181202
IS  - 1557-8607 (Electronic)
IS  - 0889-8561 (Linking)
VI  - 33
IP  - 4
DP  - 2013 Nov
TI  - Role of the B1 bradykinin receptor and gC1qR/p33 in angioedema.
PG  - 535-44
LID - S0889-8561(13)00059-3 [pii]
LID - 10.1016/j.iac.2013.07.008 [doi]
AB  - Patients affected by angioedema (AE) are subject to asymmetric, nonerythematous, 
      nonpruritic, localized, transient, episodic swelling of deeper layers or 
      submucosal tissues of the skin, oropharyngolaryngeal tissue, and/or 
      gastrointestinal wall. The nonapeptide bradykinin (BK) may be largely responsible 
      for the vascular permeability seen in most AE. During AE attacks, activation of 
      the serine proteases leads to the release of BK. Enzymes expressed on the 
      endothelial cell membrane can metabolize BK, producing the agonist of the B1R, 
      which can then be upregulated by proinflammatory stimuli, suggesting that the 
      blockade of B1R and B2R, or gC1q/p33, may provide novel therapeutic targets.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Bossi, Fleur
AU  - Bossi F
AD  - Department of Life Sciences, University of Trieste, via Valerio 28, Trieste 
      34127, Italy; Department of Medical, Surgical and Health Sciences, University of 
      Trieste, Strada di Fiume 447, Trieste 34149, Italy. Electronic address: 
      fbossi@units.it.
FAU - Tedesco, Francesco
AU  - Tedesco F
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130905
PL  - United States
TA  - Immunol Allergy Clin North Am
JT  - Immunology and allergy clinics of North America
JID - 8805635
RN  - 0 (C1QBP protein, human)
RN  - 0 (Carrier Proteins)
RN  - 0 (Mitochondrial Proteins)
RN  - 0 (Receptor, Bradykinin B1)
RN  - S8TIM42R2W (Bradykinin)
SB  - IM
MH  - Angioedema/diagnosis/*metabolism
MH  - Bradykinin/metabolism
MH  - Carrier Proteins/*metabolism
MH  - Endothelial Cells/metabolism
MH  - Humans
MH  - Mitochondrial Proteins/*metabolism
MH  - Receptor, Bradykinin B1/*metabolism
OTO - NOTNLM
OT  - Angioedema
OT  - BK 1 receptor
OT  - BK 2 receptor
OT  - Vascular leakage
OT  - gC1qR/p33
EDAT- 2013/11/02 06:00
MHDA- 2014/06/10 06:00
CRDT- 2013/11/02 06:00
PHST- 2013/11/02 06:00 [entrez]
PHST- 2013/11/02 06:00 [pubmed]
PHST- 2014/06/10 06:00 [medline]
AID - S0889-8561(13)00059-3 [pii]
AID - 10.1016/j.iac.2013.07.008 [doi]
PST - ppublish
SO  - Immunol Allergy Clin North Am. 2013 Nov;33(4):535-44. doi: 
      10.1016/j.iac.2013.07.008. Epub 2013 Sep 5.