PMID- 24177002
OWN - NLM
STAT- MEDLINE
DCOM- 20141217
LR  - 20220129
IS  - 1399-3003 (Electronic)
IS  - 0903-1936 (Linking)
VI  - 43
IP  - 5
DP  - 2014 May
TI  - The 4-metre gait speed in COPD: responsiveness and minimal clinically important 
      difference.
PG  - 1298-305
LID - 10.1183/09031936.00088113 [doi]
AB  - Usual gait speed is a consistent predictor of adverse outcomes in 
      community-dwelling elderly people. The reliability and validity of the 4-m gait 
      speed (4MGS) has recently been demonstrated in patients with chronic obstructive 
      pulmonary disease (COPD). The aims of this study were to assess the 
      responsiveness of the 4MGS and to estimate the minimal clinically important 
      difference (MCID). In 301 COPD patients, 4MGS and incremental shuttle walk (ISW) 
      were measured before and after pulmonary rehabilitation. 4MGS and ISW were also 
      measured at baseline and 1 year later in a separate cohort of 162 COPD patients. 
      The MCID of 4MGS was estimated using distribution and anchor-based methods. 4MGS 
      improved significantly with pulmonary rehabilitation (mean change 0.08 m.s(-1), 
      p<0.001). The minimal detectable change at 95% confidence was 0.11 m.s(-1). The 
      MCID was estimated at 0.11 m.s(-1) (anchored against ISW) and 0.08 m.s(-1) 
      (anchored against self-reported improvement). The effect size for 4MGS was 
      greatest in frail individuals. After 12 months, mean 4MGS declined by 0.04 
      m.s(-1). When anchored against a decline of more than the MCID for ISW, change in 
      4MGS was -0.11 m.s(-1). The 4MGS is responsive to pulmonary rehabilitation and 
      longitudinal change in COPD, and has potential as a simple functional assessment 
      tool in COPD. The 4MGS may be particularly useful in frail individuals with COPD.
FAU - Kon, Samantha S C
AU  - Kon SS
AD  - Royal Brompton and Harefield NHS Foundation Trust and Imperial College, London.
FAU - Canavan, Jane L
AU  - Canavan JL
FAU - Nolan, Claire M
AU  - Nolan CM
FAU - Clark, Amy L
AU  - Clark AL
FAU - Jones, Sarah E
AU  - Jones SE
FAU - Cullinan, Paul
AU  - Cullinan P
FAU - Polkey, Michael I
AU  - Polkey MI
FAU - Man, William D-C
AU  - Man WD
LA  - eng
GR  - CTF-01-12-04/DH_/Department of Health/United Kingdom
GR  - DHCS/07/07/009/DH_/Department of Health/United Kingdom
GR  - G1002113/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131031
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
SB  - IM
CIN - Eur Respir J. 2014 Jun;43(6):1819-20. PMID: 24881064
CIN - Eur Respir J. 2014 Jun;43(6):1820-2. PMID: 24881065
MH  - Aged
MH  - Body Mass Index
MH  - Cohort Studies
MH  - Data Interpretation, Statistical
MH  - Exercise Test/methods
MH  - Female
MH  - *Gait
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic Obstructive/*physiopathology/rehabilitation/*therapy
MH  - Quality of Life
MH  - Reproducibility of Results
MH  - Treatment Outcome
EDAT- 2013/11/02 06:00
MHDA- 2014/12/18 06:00
CRDT- 2013/11/02 06:00
PHST- 2013/11/02 06:00 [entrez]
PHST- 2013/11/02 06:00 [pubmed]
PHST- 2014/12/18 06:00 [medline]
AID - 09031936.00088113 [pii]
AID - 10.1183/09031936.00088113 [doi]
PST - ppublish
SO  - Eur Respir J. 2014 May;43(5):1298-305. doi: 10.1183/09031936.00088113. Epub 2013 
      Oct 31.