PMID- 24177209 OWN - NLM STAT- MEDLINE DCOM- 20140804 LR - 20131216 IS - 1872-7549 (Electronic) IS - 0166-4328 (Linking) VI - 259 DP - 2014 Feb 1 TI - Prenatal lipopolysaccharide exposure increases depression-like behaviors and reduces hippocampal neurogenesis in adult rats. PG - 24-34 LID - S0166-4328(13)00649-9 [pii] LID - 10.1016/j.bbr.2013.10.034 [doi] AB - Major depression is one of the most prevalent mental disorders in the population. In addition to genetic influences, disturbances in fetal nervous system development might be a contributing factor. Maternal infection during pregnancy may affect fetal brain development and consequently lead to neurological and mental disorders. Previously, we used low-dose lipopolysaccharide (LPS) exposure on embryonic day 10.5 to mimic mild maternal infection in rats and found that dopaminergic and serotonergic neurons were reduced in the offspring. The offspring also showed more anxiety-like behavior and an enhanced stress response. In the present study we used forced swim test and chronic mild stress challenge to assess depression-like behaviors in the affected offspring and examined their adult hippocampal neurogenesis and brain-derived neurotrophic factor (BDNF) concentration. Our results showed that prenatally LPS-exposed rats (LPS rats) displayed more depression-like behaviors and had reduced adult neurogenesis and BDNF. The behavioral abnormalities and reduction in adult neurogenesis could be reversed by chronic fluoxetine (FLX) treatment. This study demonstrates that during the critical time of embryonic development LPS exposure can produce long-term behavioral changes and reduction in adult neurogenesis. The findings of enhanced depression-like behaviors, reduced adult neurogenesis, and their responsiveness to chronic antidepressant treatment suggest that prenatal LPS exposure could serve as an animal model of depression. CI - Copyright (c) 2013 Elsevier B.V. All rights reserved. FAU - Lin, Yu-Lung AU - Lin YL AD - Division of Mental Health and Addiction Medicine, Institute of Population Health Sciences, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan, ROC; Graduate Institute of Life Sciences, National Defense Medical Center, 161, Section 6, Minquan E. Road, Neihu District, Taipei 114, Taiwan, ROC. FAU - Wang, Sabrina AU - Wang S AD - Division of Mental Health and Addiction Medicine, Institute of Population Health Sciences, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 350, Taiwan, ROC; Institute of Anatomy and Cell Biology, School of Medicine, National Yang-Ming University, 155, Section 2, Li-Nung Street, Beitou District, Taipei 112, Taiwan, ROC; Department of Education and Research, Taipei City Hospital, 145 Zhengzhou Road, Datong District, Taipei 103, Taiwan, ROC. Electronic address: sabrinaw.wang@gmail.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20131028 PL - Netherlands TA - Behav Brain Res JT - Behavioural brain research JID - 8004872 RN - 0 (Antidepressive Agents, Second-Generation) RN - 0 (Lipopolysaccharides) RN - 01K63SUP8D (Fluoxetine) SB - IM MH - Age Factors MH - Animals MH - Antidepressive Agents, Second-Generation/therapeutic use MH - Cell Proliferation/drug effects MH - Depression/chemically induced/drug therapy/*pathology/*physiopathology MH - Female MH - Fluoxetine/therapeutic use MH - Food Preferences/physiology/psychology MH - Hippocampus/*physiopathology/ultrastructure MH - Lipopolysaccharides/*toxicity MH - Male MH - Neurogenesis/drug effects/*physiology MH - Pregnancy MH - Prenatal Exposure Delayed Effects/chemically induced/*physiopathology MH - Rats MH - Rats, Sprague-Dawley MH - Sex Factors MH - Stress, Psychological/drug therapy/etiology MH - Time Factors OTO - NOTNLM OT - 5-HT OT - Adult neurogenesis OT - BDNF OT - DA OT - Depression OT - FLX OT - LPS OT - Maternal infection OT - Prenatal OT - Stress OT - brain-derived neurotrophic factor OT - dopamine OT - fluoxetine OT - lipopolysaccharide OT - polyI:C OT - polyriboinosinic-polyribocytidylic acid OT - serotonin EDAT- 2013/11/02 06:00 MHDA- 2014/08/05 06:00 CRDT- 2013/11/02 06:00 PHST- 2013/09/06 00:00 [received] PHST- 2013/10/18 00:00 [revised] PHST- 2013/10/20 00:00 [accepted] PHST- 2013/11/02 06:00 [entrez] PHST- 2013/11/02 06:00 [pubmed] PHST- 2014/08/05 06:00 [medline] AID - S0166-4328(13)00649-9 [pii] AID - 10.1016/j.bbr.2013.10.034 [doi] PST - ppublish SO - Behav Brain Res. 2014 Feb 1;259:24-34. doi: 10.1016/j.bbr.2013.10.034. Epub 2013 Oct 28.