PMID- 24177682
OWN - NLM
STAT- MEDLINE
DCOM- 20140325
LR  - 20131101
IS  - 1479-9731 (Electronic)
IS  - 1479-9723 (Linking)
VI  - 10
IP  - 4
DP  - 2013
TI  - Directly measured physical activity as a predictor of hospitalizations in 
      patients with chronic obstructive pulmonary disease.
PG  - 207-13
LID - 10.1177/1479972313505880 [doi]
AB  - Patients with clinically stable chronic obstructive pulmonary disease (COPD) are 
      physically inactive, and this inactivity appears to be an independent predictor 
      of hospitalizations. To explore this relationship further, we compared physical 
      activity of COPD patients assessed in 2008 to subsequent hospitalizations and 
      mortality. Sixty adults with a history of cigarette smoking, a diagnosis of COPD, 
      a forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) of 
      <0.70, and no recent exacerbation were studied. Physical activity was measured 
      using a triaxial accelerometerworn on the waist for seven consecutive days and 
      the vector magnitude units (VMUs) that are the sum of movements in three planes 
      over each minute were recorded. Those patients with mean VMU<170 (the median) 
      were considered to be less physically active, and those with a 6-minute walk 
      distance (6MWD) test of <350 m were considered to have lower functional exercise 
      capacity. These two variables, along with age, gender, and a history of 
      exacerbations in the preceding 12 months, FEV1, body mass index, and supplemental 
      oxygen requirement, were related to subsequent all-cause and respiratory-related 
      hospitalizations that occurred over the ensuing 53+/-2 months. The mean age was 
      68+/-11 years, 50% were male, and the FEV1 was 53+/-19%. All-cause and 
      respiratory-related hospitalizations occurred in 58 and 35%, respectively. A 
      6MWD<350 m and VMU<170 each significantly predicted subsequent all-cause and 
      respiratory-related hospitalizations in univariate Cox proportional hazards 
      analyses after controlling for previous exacerbations. Both 6MWD<350 m and 
      VMU<170 counts remained in a multivariate model predicting respiratory-related 
      hospitalization. These results indicate that both directly measured physical 
      activity and functional exercise capacity are important predictors of 
      hospitalization in COPD.
FAU - Zanoria, Sheila Jane T
AU  - Zanoria SJ
AD  - 1Internal Medicine, University of Connecticut Health Center, CT, USA.
FAU - ZuWallack, Richard
AU  - ZuWallack R
LA  - eng
PT  - Journal Article
PL  - England
TA  - Chron Respir Dis
JT  - Chronic respiratory disease
JID - 101197408
SB  - IM
MH  - Accelerometry
MH  - Aged
MH  - Female
MH  - Forced Expiratory Volume
MH  - Forecasting
MH  - *Hospitalization
MH  - Humans
MH  - Male
MH  - *Motor Activity
MH  - Proportional Hazards Models
MH  - Pulmonary Disease, Chronic Obstructive/mortality/*physiopathology/*therapy
MH  - Vital Capacity
OTO - NOTNLM
OT  - COPD exacerbation
OT  - Chronic obstructive pulmonary disease
OT  - accelerometer
OT  - health care utilization
OT  - vector magnitude units
EDAT- 2013/11/02 06:00
MHDA- 2014/03/26 06:00
CRDT- 2013/11/02 06:00
PHST- 2013/11/02 06:00 [entrez]
PHST- 2013/11/02 06:00 [pubmed]
PHST- 2014/03/26 06:00 [medline]
AID - 10/4/207 [pii]
AID - 10.1177/1479972313505880 [doi]
PST - ppublish
SO  - Chron Respir Dis. 2013;10(4):207-13. doi: 10.1177/1479972313505880.