PMID- 24178067
OWN - NLM
STAT- MEDLINE
DCOM- 20141208
LR  - 20211021
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 34
IP  - 5
DP  - 2014 May
TI  - Elevated serum level of growth arrest-specific protein 6 (Gas6) in systemic lupus 
      erythematosus patients is associated with nephritis and cutaneous vasculitis.
PG  - 625-9
LID - 10.1007/s00296-013-2882-1 [doi]
AB  - Growth arrest-specific protein 6 (Gas6) is a serum protein involved in 
      granulocyte, platelet and endothelium interaction, and is implicated in both 
      anti-inflammatory response as well as platelet/leukocytes activation. We 
      investigated serum Gas6 level in different clinical manifestations of systemic 
      lupus erythematosus (SLE). Data were collected in 83 patients with SLE and 40 
      non-lupus controls. The Gas6 levels were detected by enzyme-linked immunosorbent 
      assay. Our results demonstrated that the Gas6 level was higher in SLE patients as 
      compared to the non-lupus control subjects (SLE vs. non-lupus control, median 
      [inter-quartile range (IQR)] 22.67 [19.40-28.60] vs. 18.97 [16.05-20.62] ng/mL, 
      p < 0.01). Furthermore, Gas6 level was higher in patients with nephritis 
      (nephritis vs. non-nephritis, median [IQR] 26.21 [21.17-31.61] vs. 22.22 
      [18.98-26.98] ng/mL, p = 0.03) and in patients with cutaneous vasculitis 
      (vasculitis vs. non-vasculitis, median [IQR] 27.89 [23.24-34.26] vs. 22.30 
      [19.32-27.16] ng/mL, p = 0.03). Our results indicate that the serum Gas6 level is 
      increased in SLE patients with lupus nephritis or cutaneous vasculitis, 
      implicating a potential to serve as a SLE disease activity marker.
FAU - Wu, Chien-Sheng
AU  - Wu CS
AD  - Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, 
      Taiwan.
FAU - Hu, Chung-Yi
AU  - Hu CY
FAU - Tsai, Hwei-Fang
AU  - Tsai HF
FAU - Chyuan, I-Tsu
AU  - Chyuan IT
FAU - Chan, Cheng-Ju
AU  - Chan CJ
FAU - Chang, Sheng-Kai
AU  - Chang SK
FAU - Hsu, Ping-Ning
AU  - Hsu PN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131101
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Biomarkers)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (growth arrest-specific protein 6)
SB  - IM
CIN - Rheumatol Int. 2014 Aug;34(8):1171-2. PMID: 24306267
MH  - Adult
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*blood
MH  - Lupus Erythematosus, Systemic/*blood/diagnosis
MH  - Lupus Nephritis/*blood/diagnosis
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Up-Regulation
MH  - Vasculitis/*blood/diagnosis
EDAT- 2013/11/02 06:00
MHDA- 2014/12/15 06:00
CRDT- 2013/11/02 06:00
PHST- 2013/06/21 00:00 [received]
PHST- 2013/10/11 00:00 [accepted]
PHST- 2013/11/02 06:00 [entrez]
PHST- 2013/11/02 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1007/s00296-013-2882-1 [doi]
PST - ppublish
SO  - Rheumatol Int. 2014 May;34(5):625-9. doi: 10.1007/s00296-013-2882-1. Epub 2013 
      Nov 1.