PMID- 24178584
OWN - NLM
STAT- MEDLINE
DCOM- 20151116
LR  - 20211021
IS  - 1573-6695 (Electronic)
IS  - 1389-4986 (Print)
IS  - 1389-4986 (Linking)
VI  - 15
IP  - 6
DP  - 2014 Dec
TI  - Reducing aggression and impulsivity through school-based prevention programs: a 
      gene by intervention interaction.
PG  - 831-40
LID - 10.1007/s11121-013-0441-3 [doi]
AB  - A variety of school-based, universal preventive interventions have been developed 
      to address behavioral and mental health problems. Unfortunately, few have been 
      evaluated within the context of randomized controlled trials with long-term 
      follow-up. Even fewer still have examined the potential genetic factors that may 
      drive differential impact of the intervention. In the present analysis, we 
      examine the extent to which the longitudinal effects of two elementary 
      school-based interventions were moderated by the brain-derived neurotrophic 
      factor (BDNF) gene, which has been linked with aggression and impulsive 
      behaviors. The sample included 678 urban, primarily African American children who 
      were randomly assigned along with their teachers to one of three first grade 
      classroom conditions: classroom-centered (CC) intervention, Family School 
      Partnership (FSP), or a control condition. The teacher ratings of the youth's 
      aggressive and impulsive behavior were obtained at baseline and in grades 6-12. 
      Single-nucleotide polymorphisms (SNPs) from the BDNF gene were extracted from the 
      genome-wide data. Longitudinal latent trait-state-error models indicated a 
      significant interaction between a particular profile of the BDNF SNP cluster (46 
      % of sample) and CC intervention on impulsivity (beta = -.27, p < .05). A similar 
      interaction was observed for the BDNF SNP cluster and the CC intervention on 
      aggression (beta = -.14, p < .05). The results suggest that the impacts of 
      preventive interventions in early elementary school on late adolescent outcomes 
      of impulsivity and aggression can be potentially modified by genetic factors, 
      such as BDNF. However, replication of these results is necessary before firm 
      conclusions can be drawn.
FAU - Musci, Rashelle J
AU  - Musci RJ
AD  - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Rm. 
      806, 624 N. Broadway, Hampton House 850t, Baltimore, MD, 21205, USA, 
      rmusci@jhsph.edu.
FAU - Bradshaw, Catherine P
AU  - Bradshaw CP
FAU - Maher, Brion
AU  - Maher B
FAU - Uhl, George R
AU  - Uhl GR
FAU - Kellam, Sheppard G
AU  - Kellam SG
FAU - Ialongo, Nicholas S
AU  - Ialongo NS
LA  - eng
GR  - T32 MH18834/MH/NIMH NIH HHS/United States
GR  - R01 DA011796/DA/NIDA NIH HHS/United States
GR  - MH57005/MH/NIMH NIH HHS/United States
GR  - T71MC08054/PHS HHS/United States
GR  - R01 MH057005/MH/NIMH NIH HHS/United States
GR  - R37 DA11796/DA/NIDA NIH HHS/United States
GR  - T32 MH018834/MH/NIMH NIH HHS/United States
GR  - ImNIH/Intramural NIH HHS/United States
GR  - R37 DA011796/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PL  - United States
TA  - Prev Sci
JT  - Prevention science : the official journal of the Society for Prevention Research
JID - 100894724
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
EIN - Prev Sci. 2014 Dec;15(6):841
MH  - Adolescent
MH  - *Aggression
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - *Child Behavior/ethnology
MH  - Female
MH  - Health Promotion/*methods
MH  - Humans
MH  - *Impulsive Behavior
MH  - Male
MH  - Polymorphism, Single Nucleotide
MH  - Preventive Psychiatry
MH  - *Risk Reduction Behavior
MH  - *School Health Services
MH  - Urban Population
PMC - PMC4007396
MID - NIHMS536930
EDAT- 2013/11/02 06:00
MHDA- 2015/11/17 06:00
PMCR- 2015/12/01
CRDT- 2013/11/02 06:00
PHST- 2013/11/02 06:00 [entrez]
PHST- 2013/11/02 06:00 [pubmed]
PHST- 2015/11/17 06:00 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - 10.1007/s11121-013-0441-3 [doi]
PST - ppublish
SO  - Prev Sci. 2014 Dec;15(6):831-40. doi: 10.1007/s11121-013-0441-3.