PMID- 24179429
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20240413
IS  - 1337-6853 (Print)
IS  - 1337-9569 (Electronic)
IS  - 1337-6853 (Linking)
VI  - 6
IP  - 2
DP  - 2013 Jun
TI  - Lipophilic chemical exposure as a cause of cardiovascular disease.
PG  - 55-62
LID - 10.2478/intox-2013-0010 [doi]
AB  - Environmental chemical exposure has been linked to numerous diseases in humans. 
      These diseases include cancers; neurological and neurodegenerative diseases; 
      metabolic disorders including type 2 diabetes, metabolic syndrome and obesity; 
      reproductive and developmental disorders; and endocrine disorders. Many studies 
      have associated the link between exposures to environmental chemicals and 
      cardiovascular disease (CVD). These chemicals include persistent organic 
      pollutants (POPs); the plastic exudates bisphenol A and phthalates; low molecular 
      weight hydrocarbons (LMWHCs); and poly nuclear aromatic hydrocarbons (PAHs). Here 
      it is reported that though the chemicals reported on differ widely in chemical 
      properties and known points of attack in humans, a common link exists between 
      them. All are lipophilic species that are found in serum. Environmentally induced 
      CVD is related to total lipophilic chemical load in the blood. Lipophiles serve 
      to promote the absorption of otherwise not absorbed toxic hydrophilic species 
      that promote CVD.
FAU - Zeliger, Harold I
AU  - Zeliger HI
AD  - Zeliger Chemical, Toxicological and Environmental Research, West Charlton, New 
      York, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Slovakia
TA  - Interdiscip Toxicol
JT  - Interdisciplinary toxicology
JID - 101528175
PMC - PMC3798856
OTO - NOTNLM
OT  - cardiovascular disease
OT  - environmental disease
OT  - heart disease
OT  - lipophilic chemicals
OT  - toxic chemicals
EDAT- 2013/11/02 06:00
MHDA- 2013/11/02 06:01
PMCR- 2013/06/01
CRDT- 2013/11/02 06:00
PHST- 2013/05/18 00:00 [received]
PHST- 2013/06/18 00:00 [revised]
PHST- 2013/06/24 00:00 [accepted]
PHST- 2013/11/02 06:00 [entrez]
PHST- 2013/11/02 06:00 [pubmed]
PHST- 2013/11/02 06:01 [medline]
PHST- 2013/06/01 00:00 [pmc-release]
AID - ITX-6-055 [pii]
AID - 10.2478/intox-2013-0010 [doi]
PST - ppublish
SO  - Interdiscip Toxicol. 2013 Jun;6(2):55-62. doi: 10.2478/intox-2013-0010.