PMID- 24179504
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 6
IP  - 5
DP  - 2013 Nov
TI  - Clinical significance of the induction of macrophage differentiation by the 
      costimulatory molecule B7-H3 in human non-small cell lung cancer.
PG  - 1253-1260
AB  - B7-H3, a member of the B7 family of molecules, is expressed in certain types of 
      human cancer and is important in tumor development and progression. Although 
      several studies have reported that the expression of B7-H3 is correlated with 
      poor outcomes in patients with cancer, its exact role in cancer remains unknown. 
      In the present study, the expression levels of B7-H3 in the pathological 
      specimens of 105 patients treated for non-small cell lung cancer (NSCLC) were 
      examined by immunohistochemistry. A high expression level of B7-H3 was observed 
      in 46.9% of the 105 NSCLC tissue specimens. These patients demonstrated a more 
      advanced tumor grade and a shorter survival time. In addition, we also examined 
      the levels of tumor-associated macrophages (TAMs) in NSCLC tissues and observed 
      that the levels were positively correlated with the expression of B7-H3, and that 
      higher levels of macrophages were associated with lower levels of infiltrating T 
      cells and a shorter survival time. These results demonstrated that TAMs are 
      important in the evasion of tumor immune surveillance in NSCLC. Furthermore, 
      through knockdown of B7-H3 by RNA interference, we observed that soluble B7-H3 
      was capable of inducing macrophages to express higher levels of macrophage 
      mannose receptor (MMR) and lower levels of human leukocyte antigen (HLA)-DR, as 
      well as higher levels of interleukin-10 (IL-10) and lower levels of IL-1beta in 
      vitro. These observations are characteristic of an anti-inflammatory/reparatory 
      (alternative/M2) phenotype. Therefore, our data suggests that B7-H3 proteins are 
      involved in the progression of NSCLC by inducing the development of monocytes 
      into anti-inflammatory cells.
FAU - Sun, Jing
AU  - Sun J
AD  - Institute of Medical Biotechnology, Suzhou Health College, Suzhou, Jiangsu 
      215009, P.R. China.
FAU - Mao, Yong
AU  - Mao Y
FAU - Zhang, Yang-Qin
AU  - Zhang YQ
FAU - Guo, Yun-DI
AU  - Guo YD
FAU - Mu, Chuan-Yong
AU  - Mu CY
FAU - Fu, Feng-Qing
AU  - Fu FQ
FAU - Zhang, Xue-Guang
AU  - Zhang XG
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20130913
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
RIN - Oncol Lett. 2014 Jun;7(6):2223. PMID: 24932315
PMC - PMC3813612
OTO - NOTNLM
OT  - B7-H3
OT  - non-small cell lung cancer
OT  - tumor-associated macrophage
EDAT- 2013/11/02 06:00
MHDA- 2013/11/02 06:01
PMCR- 2013/09/13
CRDT- 2013/11/02 06:00
PHST- 2012/12/25 00:00 [received]
PHST- 2013/06/05 00:00 [accepted]
PHST- 2013/11/02 06:00 [entrez]
PHST- 2013/11/02 06:00 [pubmed]
PHST- 2013/11/02 06:01 [medline]
PHST- 2013/09/13 00:00 [pmc-release]
AID - ol-06-05-1253 [pii]
AID - 10.3892/ol.2013.1586 [doi]
PST - ppublish
SO  - Oncol Lett. 2013 Nov;6(5):1253-1260. doi: 10.3892/ol.2013.1586. Epub 2013 Sep 13.