PMID- 24179803
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131101
LR  - 20211021
IS  - 2213-1582 (Print)
IS  - 2213-1582 (Electronic)
IS  - 2213-1582 (Linking)
VI  - 2
DP  - 2013
TI  - Polymorphism of brain derived neurotrophic factor influences beta amyloid load in 
      cognitively intact apolipoprotein E epsilon4 carriers.
PG  - 512-20
LID - 10.1016/j.nicl.2013.04.001 [doi]
AB  - Aside from apolipoprotein E (APOE), genetic risk factors for beta amyloid deposition 
      in cognitively intact individuals remain to be identified. Brain derived 
      neurotrophic factor (BDNF) modulates neural plasticity, which has been implicated 
      in Alzheimer's disease. We examined in cognitively normal older adults whether 
      the BDNF codon 66 polymorphism affects beta amyloid burden and the relationship 
      between beta amyloid burden and cognitive scores, and how this relates to the effect 
      of APOE. Amyloid load was measured by means of (18)F-flutemetamol PET in 64 
      community-recruited cognitively intact individuals (mean age 66, S.D. 5.1). 
      Recruitment was stratified according to a factorial design with APOE (epsilon4 allele 
      present vs absent) and BDNF (met allele at codon 66 present vs absent) as 
      factors. Individuals in the four resulting cells were matched by the number of 
      cases, age, and gender. Among the APOE epsilon4 carriers, BDNF met positive subjects 
      had a significantly higher amyloid load than BDNF met negative subjects, while 
      BDNF met carrier status did not have an effect in APOE epsilon4 noncarriers. This 
      interaction effect was localized to precuneus, orbitofrontal cortex, gyrus 
      rectus, and lateral prefrontal cortex. In the APOE epsilon4/BDNF met carriers, a 
      significant inverse relationship existed between episodic memory scores and 
      amyloid burden but not in any of the other groups. This hypothesis-generating 
      experiment highlights a potential role of BDNF polymorphisms in the preclinical 
      phase of beta amyloid deposition and also suggests that BDNF codon 66 polymorphisms 
      may influence resilience against beta amyloid-related effects on cognition.
FAU - Adamczuk, Katarzyna
AU  - Adamczuk K
AD  - Laboratory for Cognitive Neurology, University of Leuven, Belgium ; Alzheimer 
      Research Centre KU Leuven, Leuven Institute for Neuroscience and Disease, 
      Belgium.
FAU - De Weer, An-Sofie
AU  - De Weer AS
FAU - Nelissen, Natalie
AU  - Nelissen N
FAU - Chen, Kewei
AU  - Chen K
FAU - Sleegers, Kristel
AU  - Sleegers K
FAU - Bettens, Karolien
AU  - Bettens K
FAU - Van Broeckhoven, Christine
AU  - Van Broeckhoven C
FAU - Vandenbulcke, Mathieu
AU  - Vandenbulcke M
FAU - Thiyyagura, Pradeep
AU  - Thiyyagura P
FAU - Dupont, Patrick
AU  - Dupont P
FAU - Van Laere, Koen
AU  - Van Laere K
FAU - Reiman, Eric M
AU  - Reiman EM
FAU - Vandenberghe, Rik
AU  - Vandenberghe R
LA  - eng
PT  - Journal Article
DEP - 20130411
PL  - Netherlands
TA  - Neuroimage Clin
JT  - NeuroImage. Clinical
JID - 101597070
PMC - PMC3777754
OTO - NOTNLM
OT  - AD, Alzheimer's disease
OT  - APOE
OT  - APOE, apolipoprotein E
OT  - Alzheimer
OT  - Amyloid PET
OT  - BDNF
OT  - BDNF, brain-derived neurotrophic factor
OT  - Flutemetamol
OT  - MRI, magnetic resonance imaging
OT  - PET, positron emission tomography
OT  - PVC, partial volume correction
OT  - SUVR, standardized uptake value ratio
OT  - SUVRcomp, SUVR in composite cortical volume of interest
OT  - VOI, volume-of-interest
OT  - met, methionine
OT  - val, valine
EDAT- 2013/11/02 06:00
MHDA- 2013/11/02 06:01
PMCR- 2013/04/11
CRDT- 2013/11/02 06:00
PHST- 2013/01/10 00:00 [received]
PHST- 2013/04/03 00:00 [revised]
PHST- 2013/04/04 00:00 [accepted]
PHST- 2013/11/02 06:00 [entrez]
PHST- 2013/11/02 06:00 [pubmed]
PHST- 2013/11/02 06:01 [medline]
PHST- 2013/04/11 00:00 [pmc-release]
AID - S2213-1582(13)00040-5 [pii]
AID - 10.1016/j.nicl.2013.04.001 [doi]
PST - epublish
SO  - Neuroimage Clin. 2013 Apr 11;2:512-20. doi: 10.1016/j.nicl.2013.04.001. 
      eCollection 2013.